CV031_HUMAN
ID CV031_HUMAN Reviewed; 290 AA.
AC O95567; A0AV97;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Uncharacterized protein C22orf31;
GN Name=C22orf31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AL035364; CAA23017.1; -; mRNA.
DR EMBL; CR456405; CAG30291.1; -; mRNA.
DR EMBL; AL021393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074758; AAH74758.1; -; mRNA.
DR EMBL; BC126262; AAI26263.1; -; mRNA.
DR EMBL; BC126264; AAI26265.1; -; mRNA.
DR CCDS; CCDS13848.1; -.
DR RefSeq; NP_056185.1; NM_015370.1.
DR AlphaFoldDB; O95567; -.
DR BioGRID; 117307; 5.
DR IntAct; O95567; 3.
DR iPTMnet; O95567; -.
DR PhosphoSitePlus; O95567; -.
DR BioMuta; C22orf31; -.
DR PaxDb; O95567; -.
DR PeptideAtlas; O95567; -.
DR PRIDE; O95567; -.
DR ProteomicsDB; 50943; -.
DR Antibodypedia; 268; 96 antibodies from 16 providers.
DR DNASU; 25770; -.
DR Ensembl; ENST00000216071.5; ENSP00000216071.4; ENSG00000100249.5.
DR GeneID; 25770; -.
DR KEGG; hsa:25770; -.
DR MANE-Select; ENST00000216071.5; ENSP00000216071.4; NM_015370.2; NP_056185.1.
DR UCSC; uc003aej.2; human.
DR CTD; 25770; -.
DR DisGeNET; 25770; -.
DR GeneCards; C22orf31; -.
DR HGNC; HGNC:26931; C22orf31.
DR HPA; ENSG00000100249; Group enriched (brain, parathyroid gland, testis).
DR neXtProt; NX_O95567; -.
DR OpenTargets; ENSG00000100249; -.
DR PharmGKB; PA145149441; -.
DR VEuPathDB; HostDB:ENSG00000100249; -.
DR eggNOG; ENOG502T0JW; Eukaryota.
DR GeneTree; ENSGT00390000012489; -.
DR HOGENOM; CLU_945074_0_0_1; -.
DR InParanoid; O95567; -.
DR OMA; DMLTIHG; -.
DR OrthoDB; 1244758at2759; -.
DR PhylomeDB; O95567; -.
DR TreeFam; TF342260; -.
DR PathwayCommons; O95567; -.
DR SignaLink; O95567; -.
DR BioGRID-ORCS; 25770; 12 hits in 1043 CRISPR screens.
DR ChiTaRS; C22orf31; human.
DR GenomeRNAi; 25770; -.
DR Pharos; O95567; Tdark.
DR PRO; PR:O95567; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; O95567; protein.
DR Bgee; ENSG00000100249; Expressed in pancreatic ductal cell and 122 other tissues.
DR Genevisible; O95567; HS.
DR InterPro; IPR028970; DUF4662.
DR PANTHER; PTHR15578; PTHR15578; 1.
DR Pfam; PF15578; DUF4662; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..290
FT /note="Uncharacterized protein C22orf31"
FT /id="PRO_0000254057"
FT REGION 105..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 46
FT /note="C -> R (in dbSNP:rs9625679)"
FT /id="VAR_028808"
FT VARIANT 210
FT /note="T -> R (in dbSNP:rs714136)"
FT /id="VAR_028809"
SQ SEQUENCE 290 AA; 32655 MW; DD641137D3C38518 CRC64;
MHPINVRRDP SIPIYGLRQS ILLNTRLQDC YVDSPALTNI WMARTCAKQN INAPAPATTS
SWEVVRNPLI ASSFSLVKLV LRRQLKNKCC PPPCKFGEGK LSKRLKHKDD SVMKATQQAR
KRNFISSKSK QPAGHRRPAG GIRESKESSK EKKLTVRQDL EDRYAEHVAA TQALPQDSGT
AAWKGRVLLP ETQKRQQLSE DTLTIHGLPT EGYQALYHAV VEPMLWNPSG TPKRYSLELG
KAIKQKLWEA LCSQGAISEG AQRDRFPGRK QPGVHEEPVL KKWPKLKSKK
