ID   CV042_HUMAN             Reviewed;         251 AA.
AC   Q6IC83; A4QPH5;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Uncharacterized protein C22orf42;
GN   Name=C22orf42;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CR456485; CAG30371.1; -; mRNA.
DR   EMBL; Z83839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL008723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471095; EAW60008.1; -; Genomic_DNA.
DR   CCDS; CCDS33639.1; -.
DR   RefSeq; NP_001010859.1; NM_001010859.1.
DR   AlphaFoldDB; Q6IC83; -.
DR   BioGRID; 127282; 16.
DR   IntAct; Q6IC83; 2.
DR   STRING; 9606.ENSP00000371529; -.
DR   GlyGen; Q6IC83; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6IC83; -.
DR   PhosphoSitePlus; Q6IC83; -.
DR   BioMuta; C22orf42; -.
DR   DMDM; 74757715; -.
DR   jPOST; Q6IC83; -.
DR   MassIVE; Q6IC83; -.
DR   PaxDb; Q6IC83; -.
DR   PeptideAtlas; Q6IC83; -.
DR   PRIDE; Q6IC83; -.
DR   Antibodypedia; 11222; 10 antibodies from 7 providers.
DR   DNASU; 150297; -.
DR   Ensembl; ENST00000382097.4; ENSP00000371529.3; ENSG00000205856.4.
DR   GeneID; 150297; -.
DR   KEGG; hsa:150297; -.
DR   MANE-Select; ENST00000382097.4; ENSP00000371529.3; NM_001010859.3; NP_001010859.1.
DR   UCSC; uc003amd.4; human.
DR   CTD; 150297; -.
DR   GeneCards; C22orf42; -.
DR   HGNC; HGNC:27160; C22orf42.
DR   HPA; ENSG00000205856; Group enriched (brain, testis).
DR   neXtProt; NX_Q6IC83; -.
DR   OpenTargets; ENSG00000205856; -.
DR   PharmGKB; PA164717091; -.
DR   VEuPathDB; HostDB:ENSG00000205856; -.
DR   eggNOG; ENOG502TEFW; Eukaryota.
DR   GeneTree; ENSGT00520000056310; -.
DR   HOGENOM; CLU_1085708_0_0_1; -.
DR   InParanoid; Q6IC83; -.
DR   OMA; YEDYLCW; -.
DR   OrthoDB; 1190938at2759; -.
DR   PhylomeDB; Q6IC83; -.
DR   TreeFam; TF340710; -.
DR   PathwayCommons; Q6IC83; -.
DR   SignaLink; Q6IC83; -.
DR   BioGRID-ORCS; 150297; 11 hits in 1032 CRISPR screens.
DR   ChiTaRS; C22orf42; human.
DR   GenomeRNAi; 150297; -.
DR   Pharos; Q6IC83; Tdark.
DR   PRO; PR:Q6IC83; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q6IC83; protein.
DR   Bgee; ENSG00000205856; Expressed in sperm and 78 other tissues.
DR   Genevisible; Q6IC83; HS.
DR   InterPro; IPR042865; DRICH1-like.
DR   PANTHER; PTHR15880; PTHR15880; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..251
FT                   /note="Uncharacterized protein C22orf42"
FT                   /id="PRO_0000344364"
FT   VARIANT         73
FT                   /note="L -> P (in dbSNP:rs5998267)"
FT                   /id="VAR_045606"
SQ   SEQUENCE   251 AA;  27691 MW;  3D7BB7582B375BFF CRC64;
     MGSKLTCCLG PSGGLNCDCC RPDVGPCHEC EIPETVAATA PASTTAKPAK LDLKAKKAQL
     MQYLSLPKTP KMLKMSKGLD ARSKRWLKII WRRHGIWPLE NIGPTEDVQA SAHGGVEENM
     TSDIEIPEAK HDHRPTEDVQ VSAHGGVEEN ITSDIEISEA KHDHHLVEDL SESLSVCLED
     FMTSDLSESL SVSLEDFMTS GLSESLSVSL EDLMTPEMAK ERYEDYLCWV KMARSRLNEP
     ISSQVLGLLR L