ID   CVC1_EBVB9              Reviewed;         507 AA.
AC   P03222; Q777C7;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN   Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; ORFNames=BGLF1;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15534216; DOI=10.1073/pnas.0407320101;
RA   Johannsen E., Luftig M., Chase M.R., Weicksel S., Cahir-McFarland E.,
RA   Illanes D., Sarracino D., Kieff E.;
RT   "Proteins of purified Epstein-Barr virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16286-16291(2004).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC       2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR   EMBL; V01555; CAA24832.1; -; Genomic_DNA.
DR   EMBL; AJ507799; CAD53442.1; -; Genomic_DNA.
DR   PIR; D43044; QQBE41.
DR   RefSeq; YP_401692.1; NC_007605.1.
DR   PDB; 6W2D; EM; 4.00 A; v=1-507.
DR   PDB; 6W2E; EM; 4.40 A; v=1-507.
DR   PDB; 7BQX; EM; 4.20 A; C=1-507.
DR   PDB; 7BR7; EM; 4.30 A; C=1-507.
DR   PDBsum; 6W2D; -.
DR   PDBsum; 6W2E; -.
DR   PDBsum; 7BQX; -.
DR   PDBsum; 7BR7; -.
DR   SMR; P03222; -.
DR   BioGRID; 971744; 1.
DR   PRIDE; P03222; -.
DR   DNASU; 3783702; -.
DR   GeneID; 3783702; -.
DR   KEGG; vg:3783702; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04017; HSV_CVC1; 1.
DR   InterPro; IPR007640; UL17-like.
DR   Pfam; PF04559; Herpes_UL17; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Late protein;
KW   Reference proteome; Viral genome packaging; Viral release from host cell;
KW   Virion.
FT   CHAIN           1..507
FT                   /note="Capsid vertex component 1"
FT                   /id="PRO_0000115964"
FT   REGION          219..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  54462 MW;  59605D622EF6FC91 CRC64;
     MDVHIDNQVL SGLGTPLLVH LFVPDTVMAE LCPNRVPNCE GAWCQTLFSD RTGLTRVCRV
     FAARGMLPGR PSHRGTFTSV PVYCDEGLPE LYNPFHVAAL RFYDEGGLVG ELQIYYLSLF
     EGAKRALTDG HLIREASGVQ ESAAAMQPIP IDPGPPGGAG IEHMPVAAAQ VEHPKTYDLK
     QILLEITQEE NRGEQRLGHA GSPALCLGLR LRAGAETKAA AETSVSKHHP ALENPSNIRG
     SAGGEGGGGR AGTGGTVGVG SGALSRVPVS FSKTRRAIRE SRALVRGIAH IFSPHALYVV
     TYPELSAQGR LHRMTAVTHA SPATDLAEVS ILGAPEREFR FLISVALRIS ASFREKLAMQ
     AWTAQQEIPV VIPTSYSRIY KNSDLIREAF FTVQTRVSWE SCWVKATISN APKTPDACLW
     IDSHPLYEEG ASAWGKVIDS RPPGGLVGAA SQLVALGTDG HCVHLATTSD GQAFLVLPGG
     FVIKGQLALT PEERGYILAR HGIRREQ