CVC1_HCMVM
ID CVC1_HCMVM Reviewed; 594 AA.
AC Q6SW50; D2K3Q0;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; OrderedLocusNames=UL93;
OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=295027;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
CC -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC viral DNA encapsidation, assuring correct genome cleavage and
CC presumably stabilizing capsids that contain full-length viral genomes.
CC {ECO:0000255|HAMAP-Rule:MF_04017}.
CC -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC 2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04017}.
CC -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR EMBL; AY446894; AAR31644.1; -; Genomic_DNA.
DR RefSeq; YP_081540.1; NC_006273.2.
DR SMR; Q6SW50; -.
DR PRIDE; Q6SW50; -.
DR GeneID; 3077486; -.
DR KEGG; vg:3077486; -.
DR Reactome; R-HSA-9609690; HCMV Early Events.
DR Reactome; R-HSA-9610379; HCMV Late Events.
DR Proteomes; UP000000938; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04017; HSV_CVC1; 1.
DR InterPro; IPR007640; UL17-like.
DR Pfam; PF04559; Herpes_UL17; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host nucleus; Late protein; Reference proteome;
KW Viral genome packaging; Viral release from host cell; Virion.
FT CHAIN 1..594
FT /note="Capsid vertex component 1"
FT /id="PRO_0000417849"
FT REGION 52..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 68501 MW; F4EE0287D93B955D CRC64;
METHLYSDLA FEARFADDEQ LPLHLVLDQE VLSNEEAETL RYVYYRNVDS AGRSAGRVPS
GDEDDAPASD DAEDAVGGDR AFDRERRTWQ RACFRVLPRP LELLDYLRQS GLTVTLEKEQ
RVRMFYAVFT TLGLRCPDNR LSGAQTLHLR LVWPDGSYRD WEFLARDLLR EEMEANKRDR
QHQLATTTNH RRRGGLRNNL DNGSDRRLPE AAVASLETAV STPFFEIPNG AGTSSANGGG
RFSNLEQRVA RLLRGDEEFI YHAGPLEPPS KIRGHELVQL RLDVNPDLMY ATDPHDRDEV
ARTDEWKGAG VSRLREVWDV QHRVRLRVLW YVNSFWRSRE LSYDDHEVEL YRALDAYRAR
IAVEYVLIRA VRDEIYAVLR RDSGALPQRF ACHVPRNMSW RVVWELCRHA LALWMDRADV
RSCIIKALTP RLSRGAAAAA QRARRQRERS APKPQELLFG PRNESGPPAE RTWYADVVRC
VRTQVDLGVE VRAARCPRTG LWIVRDRRGR LRRWLSQPEV CVLYVTPDLD FYWVLPGGFA
VSSRVTLHGL AQRALRDRFQ NFEAVLARGM HVEAGRQEPE TPRVSGRRLP FDDL
