ID   CVC1_HHV11              Reviewed;         703 AA.
AC   P10201;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN   Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; OrderedLocusNames=UL17;
OS   Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10299;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA   McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA   Perry L.J., Scott J.E., Taylor P.;
RT   "The complete DNA sequence of the long unique region in the genome of
RT   herpes simplex virus type 1.";
RL   J. Gen. Virol. 69:1531-1574(1988).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=10752563; DOI=10.1007/s007050050033;
RA   Goshima F., Watanabe D., Takakuwa H., Wada K., Daikoku T., Yamada M.,
RA   Nishiyama Y.;
RT   "Herpes simplex virus UL17 protein is associated with B capsids and
RT   colocalizes with ICP35 and VP5 in infected cells.";
RL   Arch. Virol. 145:417-426(2000).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH UL25.
RX   PubMed=17531807; DOI=10.1016/j.molcel.2007.04.010;
RA   Trus B.L., Newcomb W.W., Cheng N., Cardone G., Marekov L., Homa F.L.,
RA   Brown J.C., Steven A.C.;
RT   "Allosteric signaling and a nuclear exit strategy: binding of UL25/UL17
RT   heterodimers to DNA-Filled HSV-1 capsids.";
RL   Mol. Cell 26:479-489(2007).
RN   [4]
RP   FUNCTION.
RX   PubMed=21632758; DOI=10.1128/jvi.00837-11;
RA   Toropova K., Huffman J.B., Homa F.L., Conway J.F.;
RT   "The herpes simplex virus 1 UL17 protein is the second constituent of the
RT   capsid vertex-specific component required for DNA packaging and
RT   retention.";
RL   J. Virol. 85:7513-7522(2011).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       {ECO:0000255|HAMAP-Rule:MF_04017, ECO:0000269|PubMed:17531807,
CC       ECO:0000269|PubMed:21632758}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC       2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017, ECO:0000269|PubMed:17531807}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017,
CC       ECO:0000269|PubMed:10752563}. Host nucleus {ECO:0000255|HAMAP-
CC       Rule:MF_04017, ECO:0000269|PubMed:10752563}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR   EMBL; X14112; CAA32329.1; -; Genomic_DNA.
DR   PIR; H30083; WMBET7.
DR   SMR; P10201; -.
DR   BioGRID; 971425; 8.
DR   DIP; DIP-60386N; -.
DR   IntAct; P10201; 2.
DR   PRIDE; P10201; -.
DR   Proteomes; UP000009294; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04017; HSV_CVC1; 1.
DR   InterPro; IPR007640; UL17-like.
DR   Pfam; PF04559; Herpes_UL17; 1.
PE   1: Evidence at protein level;
KW   Capsid protein; Host nucleus; Late protein; Reference proteome;
KW   Viral genome packaging; Viral release from host cell; Virion.
FT   CHAIN           1..703
FT                   /note="Capsid vertex component 1"
FT                   /id="PRO_0000115958"
FT   REGION          200..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  74582 MW;  536DAF5421BD6B4E CRC64;
     MNAHLANEVQ TISATARVGP RSLVHVIISS ECLAAAGIPL AALMRGRPGL GTAANFQVEI
     QTRAHATGDC TPWCTAFAAY VPADAVGELL APVVPAHPGL LPRASSAGGL FVSLPVVCDA
     QGVYDPYAVA ALRLAWGSGA SCARVILFSY DELVPPNTRY AADSTRIMRV CRHLCRYVAL
     LGAAAPPAAK EAAAHLSMGL GESASPRPQP LARPHAGAPA DPPIVGASDP PISPEEQLTA
     PGGDTTAAQD VSIAQENEEI LALVQRAVQD VTRRHPVRAR TGRAACGVAS GLRQGALVHQ
     AVSGGAMGAA DADAVLAGLE PPGGGRFVAP APHGPGGEDI LNDVLTLTPG TAKPRSLVEW
     LDRGWEALAG GDRPDWLWSR RSISVVLRHH YGTKQRFVVV SYENSVAWGG RRARPPLLSS
     ALATALTEAC AAERVVRPHQ LSPAGQAELL LRFPALEVPL RHPRPVLPPF DIAAEVAFTA
     RIHLACLRAL GQAIRAALQG GPRISQRLRY DFGPDQRAWL GEVTRRFPIL LENLMRAVEG
     TAPDAFFHTA YALAVLAHLG GRGGRGRRVV PLGDDLPARF ADSDGHYVFD YYSTSGDTLR
     LNNRPIAVAM DGDVSKREQS KCRFMEAVPS TAPRRVCEQY LPGESYAYLC LGFNRRLCGI
     VVFPGGFAFT INIAAYLSLS DPVARAAVLR FCRKVSSGNG RSR