ID   CVC1_HHV2H              Reviewed;         702 AA.
AC   P89440;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN   Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; OrderedLocusNames=UL17;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA   McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT   "Comparative sequence analysis of the long repeat regions and adjoining
RT   parts of the long unique regions in the genomes of herpes simplex viruses
RT   types 1 and 2.";
RL   J. Gen. Virol. 72:3057-3075(1991).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC       2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR   EMBL; Z86099; CAB06741.1; -; Genomic_DNA.
DR   PDB; 6M6G; EM; 5.39 A; k=1-702.
DR   PDB; 6M6H; EM; 4.50 A; G=1-702.
DR   PDBsum; 6M6G; -.
DR   PDBsum; 6M6H; -.
DR   SMR; P89440; -.
DR   PRIDE; P89440; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04017; HSV_CVC1; 1.
DR   InterPro; IPR007640; UL17-like.
DR   Pfam; PF04559; Herpes_UL17; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Late protein;
KW   Reference proteome; Viral genome packaging; Viral release from host cell;
KW   Virion.
FT   CHAIN           1..702
FT                   /note="Capsid vertex component 1"
FT                   /id="PRO_0000406187"
FT   REGION          200..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   702 AA;  74704 MW;  547F6407DFF488B2 CRC64;
     MNAHFANEVQ YDLTRDPSSP ASLIHVIISS ECLAAAGVPL SALVRGRPDG GAAANFRVET
     QTRAHATGDC TPWRSAFAAY VPADAVGAIL APVIPAHPDL LPRVPSAGGL FVSLPVACDA
     QGVYDPYTVA ALRLAWGPWA TCARVLLFSY DELVPPNTRY AADGARLMRL CRHFCRYVAR
     LGAAAPAAAT EAAAHLSLGM GESGTPTPQA SSVSGGAGPA VVGTPDPPIS PEEQLTAPGG
     DTATAEDVSI TQENEEILAL VQRAVQDVTR RHPVRARPKH AASGVASGLR QGALVHQAVS
     GGALGASDAE AVLAGLEPPG GGRFASRGGP RAAGEDVLND VLTLVPGTAK PRSLVEWLDR
     GWEALAGGDR PDWLWSRRSI SVVLRHHYGT KQRFVVVSYE NSVAWGGRRA RPPRLSSELA
     TALTEACAAE RVVRPHQLSP AAQTALLRRF PALEGPLRHP RPVLQPFDIA AEVAFVARIQ
     IACLRALGHS IRAALQGGPR IFQRLRYDFG PHQSEWLGEV TRRFPVLLEN LMRALEGTAP
     DAFFHTAYAL AVLAHLGGQG GRGRRRRLVP LSDDIPARFA DSDAHYAFDY YSTSGDTLRL
     TNRPIAVVID GDVNGREQSK CRFMEGSPST APHRVCEQYL PGESYAYLCL GFNRRLCGLV
     VFPGGFAFTI NTAAYLSLAD PVARAVGLRF CRGAATGPGL VR