ID   CVC1_HHV6U              Reviewed;         442 AA.
AC   P24441;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN   Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; OrderedLocusNames=10R, U64;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2152817; DOI=10.1128/jvi.64.1.287-299.1990;
RA   Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W.,
RA   Barrell B.G.;
RT   "Human herpesvirus 6 is closely related to human cytomegalovirus.";
RL   J. Virol. 64:287-299(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC       2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR   EMBL; X83413; CAA58356.1; -; Genomic_DNA.
DR   EMBL; M68963; AAA65573.1; -; Genomic_DNA.
DR   PIR; A36769; A36769.
DR   RefSeq; NP_042957.1; NC_001664.2.
DR   PRIDE; P24441; -.
DR   DNASU; 1487946; -.
DR   GeneID; 1487946; -.
DR   KEGG; vg:1487946; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04017; HSV_CVC1; 1.
DR   InterPro; IPR007640; UL17-like.
DR   Pfam; PF04559; Herpes_UL17; 2.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Late protein; Reference proteome;
KW   Viral genome packaging; Viral release from host cell; Virion.
FT   CHAIN           1..442
FT                   /note="Capsid vertex component 1"
FT                   /id="PRO_0000115959"
SQ   SEQUENCE   442 AA;  51391 MW;  9A5F3383DF05CDDB CRC64;
     METHLYYDTL YQYQGGVYPA HICLPTDVCL PMRVDCIESL YFRCVFFKSG MHYTEWSKLK
     FTVISREIKF KDVLKDADSD EVFTGLVVMT IPIPIVDFHF DIDSVILKLV YPRLVHREIV
     LRLYDLICVR PPSNRPSEAS AKNIANDFYQ LTSRENKQTP DEEKRCLFFQ QGPLEPPSTV
     RGLKAPGNEK PIQFPAHANE KMTESFLSDS WFGQKVRCKK ILDFTQTYQV VVCWYELSFS
     REMQIENNLL SASQLKRVNA ADFWDRTNRY LRDIGSRVLT HIVKTLQIHN RQFKQKFNCN
     FPDNFSFDRL LSFMQLGKDF WILNLTLDSC IIKAIICFLG FQNGGKSFLA QDEVWGDLID
     CSKGSVIYGE KIQWILDSTN NLYSTCREKQ NKSWELYVDC CALYVSEKLE LDFVLPGGFA
     ITGKFALTDG DIDFFNWRFG LS