ID   CVC1_HHV8P              Reviewed;         454 AA.
AC   F5HB39;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN   Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; OrderedLocusNames=ORF32;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC       2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR   EMBL; AF148805; ABD28883.1; -; Genomic_DNA.
DR   RefSeq; YP_001129385.1; NC_009333.1.
DR   PDB; 6PPB; EM; 4.30 A; k=1-454.
DR   PDB; 6PPH; EM; 3.80 A; k=1-454.
DR   PDBsum; 6PPB; -.
DR   PDBsum; 6PPH; -.
DR   SMR; F5HB39; -.
DR   PRIDE; F5HB39; -.
DR   GeneID; 4961479; -.
DR   KEGG; vg:4961479; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04017; HSV_CVC1; 1.
DR   InterPro; IPR007640; UL17-like.
DR   Pfam; PF04559; Herpes_UL17; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Late protein;
KW   Reference proteome; Viral genome packaging; Viral release from host cell;
KW   Virion.
FT   CHAIN           1..454
FT                   /note="Capsid vertex component 1"
FT                   /id="PRO_0000423785"
FT   REGION          197..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  49512 MW;  C1C7C4E6B7E071F4 CRC64;
     MDAHAINERY VGPRCHRLAH VVLPRTFLLH HAIPLEPEII FSTYTRFSRS PGSSRRLVVC
     GKRVLPGEEN QLASSPSGLA LSLPLFSHDG NFHPFDISVL RISCPGSNLS LTVRFLYLSL
     VVAMGAGRNN ARSPTVDGVS PPEGAVAHPL EELQRLARAT PDPALTRGPL QVLTGLLRAG
     SDGDRATHHM ALEAPGTVRG ESLDPPVSQK GPARTRHRPP PVRLSFNPVN ADVPATWRDA
     TNVYSGAPYY VCVYERGGRQ EDDWLPIPLS FPEEPVPPPP GLVFMDDLFI NTKQCDFVDT
     LEAACRTQGY TLRQRVPVAI PRDAEIADAV KSHFLEACLV LRGLASEASA WIRAATSPPL
     GRHACWMDVL GLWESRPHTL GLELRGVNCG GTDGDWLEIL KQPDVQKTVS GSLVACVIVT
     PALEAWLVLP GGFAIKGRYR ASKEDLVFIR GRYG