ID   CVC1_VZVD               Reviewed;         676 AA.
AC   P09292;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Capsid vertex component 1 {ECO:0000255|HAMAP-Rule:MF_04017};
GN   Name=CVC1 {ECO:0000255|HAMAP-Rule:MF_04017}; OrderedLocusNames=43;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with capsid vertex component
CC       2/CVC2. {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04017}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04017}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04017}.
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DR   EMBL; X04370; CAA27926.1; -; Genomic_DNA.
DR   PIR; H27341; WZBE43.
DR   SMR; P09292; -.
DR   PRIDE; P09292; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04017; HSV_CVC1; 1.
DR   InterPro; IPR007640; UL17-like.
DR   Pfam; PF04559; Herpes_UL17; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Late protein; Reference proteome;
KW   Viral genome packaging; Viral release from host cell; Virion.
FT   CHAIN           1..676
FT                   /note="Capsid vertex component 1"
FT                   /id="PRO_0000115962"
FT   REGION          253..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  73909 MW;  E25CFD38ED2B0E10 CRC64;
     MEAHLANETK HALWHNDHTK GLLHVVIPNA GLIAAGIDPA LLILKKPGQR FKVEVQTRYH
     ATGQCEPWCQ VFAAYIPDNA LTNLLIPKTE PFVSHVFSAT HNSGGLILSL PVYLSPGLFF
     DAFNVVAIRI NTGNRKHRDI CIMYAELIPN GTRYFADGQR VLLLCKQLIA YIRCTPRLAS
     SIKIYAEHMV AAMGESHTSN GDNIGPVSSI IDLDRQLTSG GIDDSPAETR IQENNRDVLE
     LIKRAVNIVN SRHPVRPSSS RVASGLLQSA KGHGAQTSNT DPINNGSFDG VLEPPGQGRF
     TGKKNNSSAS IPPLQDVLLF TPASTEPQSL MEWFDICYAQ LVSGDTPADF WKRRPLSIVP
     RHYAESPSPL IVVSYNGSSA WGGRITGSPI LYHSAQAIID AACINARVDN PQSLHVTARQ
     ELVARLPFLA NVLNNQTPLP AFKPGAEMFL NQVFKQACVT SLTQGLITEL QTNPTLQQLM
     EYDIADSSQT VIDEIVARTP DLIQTIVSVL TEMSMDAFYN SSLMYAVLAY LSSVYTRPQG
     GGYIPYLHAS FPCWLGNRSI YLFDYYNSGG EILKLSKVPV PVALEKVGIG NSTQLRGKFI
     RSADIVDIGI CSKYLPGQCY AYICLGFNQQ LQSILVLPGG FAACFCITDT LQAALPASLI
     GPILDRFCFS IPNPHK