ID   CVC2_ALHV1              Reviewed;         556 AA.
AC   O36369;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   02-JUN-2021, entry version 60.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=19;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF005370; AAC58066.1; -; Genomic_DNA.
DR   PIR; T03114; T03114.
DR   RefSeq; NP_065518.1; NC_002531.1.
DR   SMR; O36369; -.
DR   GeneID; 911754; -.
DR   KEGG; vg:911754; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..556
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000405752"
FT   REGION          1..54
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          104..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  61327 MW;  852E0566521EC3D0 CRC64;
     MWPVGSSYTR ACSVQRWPKR CVYWAPSPQN VLEINPHRFQ ESRRSAALYR KHVVESKLNL
     IKKELLKAEL DNVVQTNLAN SQAITDYLTT LEDLANILVD RAQQPASSNQ GGARPQTDPH
     VPQPAPAIPS APPKENTTTV VIAPGDSGYT FSTNFLREFL SGLYATSASW LPSYGPWFTA
     MTANAMQRRV FPKELKGTAN LKNSTSLKLI TEVLTTVASI NVDFYTDLRN LSDFNAALCI
     LNAYYCKTQG HPLPASREEL LDNLGPKIAA LVADIKGLGS DSNITFTFTF SSGQQAATIA
     PVNGDGRYNK DFFSNHKIFR LLVAKEVVLL PNFTNVPGAT DGPDYIYALT SALFSDNIPP
     FGNYQLNLRS GIKGVEYLIL VYLTLANAQL SKPDGRRLHL KALLGAAFEH SSKVQLFKRD
     EVFTFLMKEY VLPILSHNNN ISTTELFPGM ALAALEVGNQ INFDPNKHFV NLAGTKFTKI
     FNVLNQKLMF KDVRELLVAK SELRVALENG LAATLNSIAP VNAVVEVIQK QFGGGDDYDR
     LYFLVLGCLP VTVAVV