ID   CVC2_EBVG               Reviewed;         570 AA.
AC   P0C706; Q777B7;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   02-JUN-2021, entry version 31.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; ORFNames=BVRF1;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AY961628; AAY41149.1; -; Genomic_DNA.
DR   RefSeq; YP_401703.1; NC_007605.1.
DR   SMR; P0C706; -.
DR   IntAct; P0C706; 11.
DR   DNASU; 3783732; -.
DR   GeneID; 3783732; -.
DR   KEGG; vg:3783732; -.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..570
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000408274"
FT   REGION          1..54
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          102..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   570 AA;  62461 MW;  7D8D7B9E67064BAB CRC64;
     MALSGHVLID PARLPRDTGP ELMWAPSLRN SLRVSPEALE LAEREAERAR SERWDRCAQV
     LKNRLLRVEL DGIMRDHLAR AEEIRQDLDA VVAFSDGLES MQVRSPSTGG RSAPAPPSPS
     PAQPFTRLTG NAQYAVSISP TDPPLMVAGS LAQTLLGNLY GNINQWVPSF GPWYRTMSAN
     AMQRRVFPKQ LRGNLNFTNS VSLKLMTEVV AVLEGTTQDF FSDVRHLPDL QAALILSVAY
     LLLQGGSSHQ QRPLPASREE LLELGPESLE KIIADLKAKS PGGNFMILTS GNKEARQSIA
     PLNRQAAYPP GTFADNKIYN LFVGAGLLPT TAALNVPGAA GRDRDLVYRI ANQIFGEDVP
     PFSSHQWNLR VGLAALEALM LVYTLCETAN LAEAATRRLH LSSLLPQAMQ RRKPAMASAG
     MPGAYPVQTL FRHGELFRFI WAHYVRPTVA ADPQASISSL FPGLVLLALE LKLMDGQAPS
     HYAINLTGQK FDTLFEIINQ KLLFHDPAAM LAARTQLRLA FEDGVGVALG RPSPMLAARE
     ILERQFSASD DYDRLYFLTL GYLASPVAPS