CVC2_EHV1B
ID CVC2_EHV1B Reviewed; 587 AA.
AC P28928; Q6DLH4;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 02-JUN-2021, entry version 87.
DE RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=36;
OS Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=31520;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT "The DNA sequence of equine herpesvirus-1.";
RL Virology 189:304-316(1992).
CC -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC viral DNA encapsidation, assuring correct genome cleavage and
CC presumably stabilizing capsids that contain full-length viral genomes.
CC Participates in the interaction between the capsid and the tegument
CC through interaction with the large tegument protein/LTP.
CC {ECO:0000255|HAMAP-Rule:MF_04025}.
CC -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC Rule:MF_04025}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR EMBL; AY665713; AAT67294.1; -; Genomic_DNA.
DR PIR; B36799; WZBEC9.
DR RefSeq; YP_053082.1; NC_001491.2.
DR SMR; P28928; -.
DR GeneID; 1487558; -.
DR KEGG; vg:1487558; -.
DR Proteomes; UP000001189; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04025; HSV_CVC2; 1.
DR InterPro; IPR002493; Herpes_UL25.
DR Pfam; PF01499; Herpes_UL25; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW Viral genome packaging; Viral penetration into host nucleus;
KW Viral release from host cell; Virion; Virus entry into host cell.
FT CHAIN 1..587
FT /note="Capsid vertex component 2"
FT /id="PRO_0000115995"
FT REGION 1..53
FT /note="Interaction with major capsid protein/MCP"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT REGION 113..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 63692 MW; 6BE2F5FAB34CA3C8 CRC64;
MAEYVNYVLG SLYVSDTATS TIPTDVRNFI APPFPLNFWS GPTFTVSSNT RADPLKLVAA
RHRAAAAAID TLEAQSQYGV ANVDALIRPL ERQVAKVADA LAALEDAARA AESADAATPQ
VNASEADQRP DNIGQSLSEI QIAKNDVPME FDTNLAVDLL ATVFVSRAAG GSNGVVFGTW
YRALQDRLVT ERPVATRSID YRDGRMSKTF MTTAVVSLQS CGRLYIGNRP YSAFEAAVLC
LHLAHRAVNS NYTYPTSFSG LIEQLPVYIE AFSTALGDGT LGKVGYEFNG ARLPKNQFHV
PGGGGRYERG ALNGHGVLET LIRLKVLPAI PGSLGTTSTA VGPELDADQT AYIDDVNKAA
AAFLVRAQNL FLTEDQTLLR STINTITALL LLRRLLWNGN VYTDRLRNNF QLGAIVPNLA
VSQRDARGAS GGDAAAMVSR SGNNNFTFLC ERYVSPIYIA NREVELTQLF PGLAALCLDA
QTVARDQPQH RAVNVSTGRN QTNLTRLIGI ELENRRRTAP VPINEVLAAH DAVALQYERG
LGLLMQKPRL RASLEETRRL GQFNVASDYD LLYFVCLGYI PSLTSAM