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CVC2_EHV1B
ID   CVC2_EHV1B              Reviewed;         587 AA.
AC   P28928; Q6DLH4;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   02-JUN-2021, entry version 87.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=36;
OS   Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31520;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA   Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-1.";
RL   Virology 189:304-316(1992).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AY665713; AAT67294.1; -; Genomic_DNA.
DR   PIR; B36799; WZBEC9.
DR   RefSeq; YP_053082.1; NC_001491.2.
DR   SMR; P28928; -.
DR   GeneID; 1487558; -.
DR   KEGG; vg:1487558; -.
DR   Proteomes; UP000001189; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..587
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000115995"
FT   REGION          1..53
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          113..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  63692 MW;  6BE2F5FAB34CA3C8 CRC64;
     MAEYVNYVLG SLYVSDTATS TIPTDVRNFI APPFPLNFWS GPTFTVSSNT RADPLKLVAA
     RHRAAAAAID TLEAQSQYGV ANVDALIRPL ERQVAKVADA LAALEDAARA AESADAATPQ
     VNASEADQRP DNIGQSLSEI QIAKNDVPME FDTNLAVDLL ATVFVSRAAG GSNGVVFGTW
     YRALQDRLVT ERPVATRSID YRDGRMSKTF MTTAVVSLQS CGRLYIGNRP YSAFEAAVLC
     LHLAHRAVNS NYTYPTSFSG LIEQLPVYIE AFSTALGDGT LGKVGYEFNG ARLPKNQFHV
     PGGGGRYERG ALNGHGVLET LIRLKVLPAI PGSLGTTSTA VGPELDADQT AYIDDVNKAA
     AAFLVRAQNL FLTEDQTLLR STINTITALL LLRRLLWNGN VYTDRLRNNF QLGAIVPNLA
     VSQRDARGAS GGDAAAMVSR SGNNNFTFLC ERYVSPIYIA NREVELTQLF PGLAALCLDA
     QTVARDQPQH RAVNVSTGRN QTNLTRLIGI ELENRRRTAP VPINEVLAAH DAVALQYERG
     LGLLMQKPRL RASLEETRRL GQFNVASDYD LLYFVCLGYI PSLTSAM
 
 
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