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CVC2_EHV2
ID   CVC2_EHV2               Reviewed;         564 AA.
AC   Q66622;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=19;
OS   Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82831;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA   Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus 2.";
RL   J. Mol. Biol. 249:520-528(1995).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; U20824; AAC13806.1; -; Genomic_DNA.
DR   PIR; S55613; S55613.
DR   RefSeq; NP_042615.1; NC_001650.2.
DR   SMR; Q66622; -.
DR   PRIDE; Q66622; -.
DR   GeneID; 1461017; -.
DR   KEGG; vg:1461017; -.
DR   Proteomes; UP000007083; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..564
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000406169"
FT   REGION          1..45
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          91..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  61245 MW;  7E4B52FBC97248B1 CRC64;
     MQAARKRWPP SVAFWSPSPK HYVRVDRDSL RETRRLASSL RRNALAARVA RVKAGMLRAE
     LGNLSQLQIA HAHGVLADLA RLEQATALHV AGDGRGSGNP PTSPGQGHPL SWGNSDSHGG
     GGGPGGGGGG ELLITISPDG PTFSVKDDFR TEFISGLYTR QSQWLPFYGP WYAAMTDSAM
     QRRVFPKELK GNVNFQNSTS LKLMTGLLEV LASATEDFYT DGRNLSDVNA ALCLLNGYYC
     LRTPAPLPST YGELLADLDK KMEFLIADLK RDASNTDFSF AFSNPRQLET VAPLNRQGAY
     APDFFGRHKM FAVMSDAGMF PNTKQTAASA QDPGARDIVY LITNAVFGEN VPPFITYQLN
     LRTGLKALEL LIVVYIVLEN AHVQHNTVNR RLQLPALLGD QYKRPAAQRP QPQQPAAMFK
     KGFLFSFVVK NYMVPVLTRR PQTPASSLFP GAVLLALETA DAASAGGGSG QTLGGHLINL
     SGKKYDQLFD VLNQKLTFRD VQGLIGAQTA LRLTLERGLN LLLSKPSPLT SATEVISTQF
     GGGDDYDSLY FLILGCLPVT MAVV
 
 
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