CVC2_EHV2
ID CVC2_EHV2 Reviewed; 564 AA.
AC Q66622;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=19;
OS Equine herpesvirus 2 (strain 86/87) (EHV-2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX NCBI_TaxID=82831;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=7783207; DOI=10.1006/jmbi.1995.0314;
RA Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.;
RT "The DNA sequence of equine herpesvirus 2.";
RL J. Mol. Biol. 249:520-528(1995).
CC -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC viral DNA encapsidation, assuring correct genome cleavage and
CC presumably stabilizing capsids that contain full-length viral genomes.
CC Participates in the interaction between the capsid and the tegument
CC through interaction with the large tegument protein/LTP.
CC {ECO:0000255|HAMAP-Rule:MF_04025}.
CC -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC Rule:MF_04025}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR EMBL; U20824; AAC13806.1; -; Genomic_DNA.
DR PIR; S55613; S55613.
DR RefSeq; NP_042615.1; NC_001650.2.
DR SMR; Q66622; -.
DR PRIDE; Q66622; -.
DR GeneID; 1461017; -.
DR KEGG; vg:1461017; -.
DR Proteomes; UP000007083; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04025; HSV_CVC2; 1.
DR InterPro; IPR002493; Herpes_UL25.
DR Pfam; PF01499; Herpes_UL25; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW Viral genome packaging; Viral penetration into host nucleus;
KW Viral release from host cell; Virion; Virus entry into host cell.
FT CHAIN 1..564
FT /note="Capsid vertex component 2"
FT /id="PRO_0000406169"
FT REGION 1..45
FT /note="Interaction with major capsid protein/MCP"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT REGION 91..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 61245 MW; 7E4B52FBC97248B1 CRC64;
MQAARKRWPP SVAFWSPSPK HYVRVDRDSL RETRRLASSL RRNALAARVA RVKAGMLRAE
LGNLSQLQIA HAHGVLADLA RLEQATALHV AGDGRGSGNP PTSPGQGHPL SWGNSDSHGG
GGGPGGGGGG ELLITISPDG PTFSVKDDFR TEFISGLYTR QSQWLPFYGP WYAAMTDSAM
QRRVFPKELK GNVNFQNSTS LKLMTGLLEV LASATEDFYT DGRNLSDVNA ALCLLNGYYC
LRTPAPLPST YGELLADLDK KMEFLIADLK RDASNTDFSF AFSNPRQLET VAPLNRQGAY
APDFFGRHKM FAVMSDAGMF PNTKQTAASA QDPGARDIVY LITNAVFGEN VPPFITYQLN
LRTGLKALEL LIVVYIVLEN AHVQHNTVNR RLQLPALLGD QYKRPAAQRP QPQQPAAMFK
KGFLFSFVVK NYMVPVLTRR PQTPASSLFP GAVLLALETA DAASAGGGSG QTLGGHLINL
SGKKYDQLFD VLNQKLTFRD VQGLIGAQTA LRLTLERGLN LLLSKPSPLT SATEVISTQF
GGGDDYDSLY FLILGCLPVT MAVV