ID   CVC2_GAHVM              Reviewed;         583 AA.
AC   Q9E6P3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=MDV037;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AF243438; AAG14217.1; -; Genomic_DNA.
DR   RefSeq; YP_001033953.1; NC_002229.3.
DR   GeneID; 4811497; -.
DR   KEGG; vg:4811497; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..583
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000406512"
FT   REGION          1..49
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   583 AA;  64742 MW;  1A5665AF07938D6F CRC64;
     MANFIWDARI LTGDGMEMFP ADVKNFIAPP WPIEFWKEPV FTSNRANMER QLAIITARNN
     AATAALNNLD GHTDSIAIEI DRRLRPIEEK IEHIATALAD LEHAAAAAEL ADAAMDIAVS
     AVEKSGQHKE DVNITSAREI QIVKNDPLLR YDSNLSVDLL NLVYANRNVV NSGVVFGTWY
     RTLQNALVAD KPSVARKIDY HGGRMSRTFI VTAITSLQSC GRLYVGTRYY SSLECAILCL
     YAFYAKTGTN ISHPTNFMSA IESVPTYLEH LSTRLASSDS RQKYGFDWAR LPKDTFDSPC
     GKYERGALHD HSILRALVNS RVLPPGAGSL PRGDVIPEID AEQGIRNDEV NRAAAALLGR
     AQPLFLMEDQ PLLRSTIDTI TALLLLHRLL WNTNIYSARV KNIFQLGAFV PGIVPDLTVG
     ASVDTPGDII KSDGRNLMFL FQRYVAPMYG TVKGIEFTQL FPGLVALCLD VPLFSGGIFS
     HRAPLSRVVD VSLGKYQASL VKLISLELEN RSRANIVSVC EVITAHDLVT LQYEQGLESL
     MQIQRPRSRL FETKKLSAFN VETDYDLIYF ICLGYIPKLI STL