ID   CVC2_HCMVM              Reviewed;         636 AA.
AC   Q6SW65; D2K3N5;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=UL77;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AY446894; AAR31629.1; -; Genomic_DNA.
DR   RefSeq; YP_081525.1; NC_006273.2.
DR   SMR; Q6SW65; -.
DR   BioGRID; 1678004; 1.
DR   PRIDE; Q6SW65; -.
DR   GeneID; 3077451; -.
DR   KEGG; vg:3077451; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..636
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000418317"
FT   REGION          1..48
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          97..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  70644 MW;  D2C0A57D85F33CC4 CRC64;
     MSLLHTFWRL PVAVFFEPHE ENVLRCPERV LRRLLEDAAV AMRGGGWRED VLMDRVRKRY
     LRQELRDLGH RVQTYCEDLE GRVSEAEALL NQQCELDEGP SPRTLLQPPC RPRSSSPGTG
     VAGASAVPHG LYSRHDAITG PVAAPSDAVA ASAAAGASST WLAQCAEQPL PGNVPNYFGI
     TQNDPFIRFH TDFRGEVVNT MFENASTWTF SFGIWYYRLK RGLYTQPRWK RVYHLAQMDN
     FSISQELLLG VVNALENVTV YPTYDCVLSD LEAAACLLVA YGHALWEGRD PPDSVTAVLS
     ELPQLLPRLA DDVSREIAAW EGPVAAGNNY YAYRDSPDLR YYMPLSGGRH YHPGTFDRHV
     LVRLFHKRGV LQHLPGYGTI TEELVQERLS GQVRDDVLSL WSRRLLVGKL GRDVPVFVHE
     QQYLRSGLTC LAGLLLLWKV TNADSVFAPR TGKFTLADLL GSDAVAGGGL PGGRAGGEEK
     GYGGRHGRVR NFEFLVQYYI GPWYARDPAV TLSQLFPGLA LLAVTESVRS GWDPSRREDS
     AGGGDGGGAV LMQLSKSNPV ADYMFAQSSK QYGDLRRLEV HDALLFHYEH GLGRLLSVTL
     PRHRVSTLGS SLFNVNDIYE LLYFLVLGFL PSVAVL