ID   CVC2_HHV2H              Reviewed;         585 AA.
AC   P89448;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   29-SEP-2021, entry version 78.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=UL25;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA   McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT   "Comparative sequence analysis of the long repeat regions and adjoining
RT   parts of the long unique regions in the genomes of herpes simplex viruses
RT   types 1 and 2.";
RL   J. Gen. Virol. 72:3057-3075(1991).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; Z86099; CAB06749.1; -; Genomic_DNA.
DR   PDB; 6M6G; EM; 5.39 A; l/m=1-585.
DR   PDB; 6M6H; EM; 4.50 A; H/I=1-585.
DR   PDBsum; 6M6G; -.
DR   PDBsum; 6M6H; -.
DR   SMR; P89448; -.
DR   PRIDE; P89448; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Host-virus interaction;
KW   Reference proteome; Viral genome packaging;
KW   Viral penetration into host nucleus; Viral release from host cell; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..585
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000406178"
FT   REGION          1..49
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          109..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   585 AA;  63568 MW;  DE9D7F849268884C CRC64;
     MDPYYPFDAL DVWEHRRFIV ADSRSFITPE FPRDFWMLPV FNIPRETAAE RAAVLQAQRT
     AAAAALENAA LQAAELPVDI ERRIRPIEQQ VHHIADALEA LETAAAAAEE ADAARDAEAR
     GEGAADGAAP SPTAGPAAAE MEVQIVRNDP PLRYDTNLPV DLLHMVYAGR GAAGSSGVVF
     GTWYRTIQER TIADFPLTTR SADFRDGRMS KTFMTALVLS LQSCGRLYVG QRHYSAFECA
     VLCLYLLYRT THESSPDRDR APVAFGDLLA RLPRYLARLA AVIGDESGRP QYRYRDDKLP
     KAQFAAAGGR YEHGALATHV VIATLVRHGV LPAAPGDVPR DTSTRVNPDD VAHRDDVNRA
     AAAFLARGHN LFLWEDQTLL RATANTITAL AVLRRLLANG NVYADRLDNR LQLGMLIPGA
     VPAEAIARGA SGLDSGAIKS GDNNLEALCV NYVLPLYQAD PTVELTQLFP GLAALCLDAQ
     AGRPLASTRR VVDMSSGARQ AALVRLTALE LINRTRTNTT PVGEIINAHD ALGIQYEQGP
     GLLAQQARIG LASNTKRFAT FNVGSDYDLL YFLCLGFIPQ YLSVA