ID   CVC2_HHV6U              Reviewed;         555 AA.
AC   P52387;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 80.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; ORFNames=BHRF3, U50;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-378.
RX   PubMed=1333836; DOI=10.3109/10425179209039693;
RA   Gompels U.A., Carss A.L., Sun N., Arrand J.R.;
RT   "Infectivity determinants encoded in a conserved gene block of human
RT   herpesvirus-6.";
RL   DNA Seq. 3:25-39(1992).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; X83413; CAA58384.1; -; Genomic_DNA.
DR   EMBL; X64320; CAA45605.1; -; Genomic_DNA.
DR   RefSeq; NP_042943.1; NC_001664.2.
DR   SMR; P52387; -.
DR   PRIDE; P52387; -.
DR   DNASU; 1487930; -.
DR   GeneID; 1487930; -.
DR   KEGG; vg:1487930; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..555
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000115998"
FT   REGION          1..47
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   555 AA;  63594 MW;  BA0C879FF56130D4 CRC64;
     MAQCNLFYQY PITPILEGHV RNILICTEKD VEKLQSQSSL RLREKIDQGH RDKLLRMRLK
     TELDALQKKM QKDSDVLNSH LKAIEDALLF TNDGEVNVET KADAQLIPKS PEKLEKFNQV
     AITPLDPFIR FTDDFRGEMI NTFFNNAQMW NFTFGSWFYK LKRVFYNEPG LRRALKLTNV
     DSLTISKELL AVTVNALEQA TVYPIFGSEM SDLEAALCIL AAFYSTYENS QIDERTTLVD
     VITLLPVIFR LLGSEITALK NVSPSGTYFG FNDPSCMKFF VPMRKGKHYA ENTFGNHVLI
     KMLLGRGVMQ KIPGEKISQN FDVEARLHGA IKNDVLVYWT YQLMRPKLGN NVPIFIHDQH
     YLRSGLVAIE SLFLLWRILN SESLFNKRVG KFLLTSIFPQ LENVDFAENN FEAGNIQNFE
     YLMHHYVVPM YNLQNDISIS TLFPGLVAVC VNESVRLGWE HKCAGAPSDA VQVQSKENPF
     VEYIRAQMEQ QADVAILEKH DCILFHLENG LNITLSFTLP RQRLFAMASS LFNVNDTYDF
     IYFLVLGFLP IPAVI