ID   CVC2_HHV6Z              Reviewed;         555 AA.
AC   P52537;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 80.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=KA11R, U50;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7983761; DOI=10.1128/jvi.69.1.589-596.1995;
RA   Stamey F.R., Dominguez G., Black J.B., Dambaugh T.R., Pellett P.E.;
RT   "Intragenomic linear amplification of human herpesvirus 6B oriLyt suggests
RT   acquisition of oriLyt by transposition.";
RL   J. Virol. 69:589-596(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AF157706; AAB06348.1; -; Genomic_DNA.
DR   PIR; T44010; T44010.
DR   RefSeq; NP_050231.1; NC_000898.1.
DR   SMR; P52537; -.
DR   PRIDE; P52537; -.
DR   DNASU; 1497052; -.
DR   GeneID; 1497052; -.
DR   KEGG; vg:1497052; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..555
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000115999"
FT   REGION          1..47
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   555 AA;  63831 MW;  68B86590DC4CD2BC CRC64;
     MAQCNLFYQY PITPILEGHV RNILICTEED IRRLQSQSSL RLREKIDQGH RDKLLRMRLK
     TELDALQRKM QKDSDVLNSH LKAIEDALLF TNDGEVNVET KADTQLLPKS PERLEKFNQV
     AITPLDPFIR FTDDFRGEMI NTFFNNAQMW NFTFGSWFYK LKRVFYNEPG LRRALKITNV
     DSLTISKELL TVTVNALEQA TVYPIFGSEM SDLEAALCIL AAFYSTYENS QIDERTTLVD
     IITLLPVIFR LLGSEITALK NVSPSGTYFG FNDPSCMKFF VPMRKGKHYA ENTFGNHVLV
     KMLLGRGVMQ KIPGEKDSQN FDVEARLHGA IKNDVLVYWT YQLMRPKLGN NVPIFIHDQH
     YLRSGLVAIE SLFLLWRILN SESLFNKRVG KFLLTSIFPQ LENVDFAENN FEAGNIQNFE
     YLMHHYVVPM YNLQNDISIS TLFPGLVAVC VNESVRLGWE HKCAGAPSDA VQVQSKENPF
     VEYIRAQMEQ QADVAILEKH DCILFHFENG LNITLSFTLP RQRLFAMASS LFNVNDTYDF
     IYFLVLGFLP IPAII