ID   CVC2_HHV7J              Reviewed;         554 AA.
AC   P52388;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 74.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=U50;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; U43400; AAC54712.1; -; Genomic_DNA.
DR   PIR; T41952; T41952.
DR   SMR; P52388; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..554
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000116000"
FT   REGION          1..46
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   554 AA;  63940 MW;  9D3EDD55B09493E9 CRC64;
     MTQLSLFYQF PIQPIFEGHV RNTLICTEED MQQLQNLGIR KLRKEKEEIQ KNKILKNLLK
     TELDVLQAHV QTECQKLNTN LRDIENALLL ENQKIIPSSE THSVLEESLQ AKTVTQVTIT
     QIDPAIHFTE NFRPEMIKTF YNNTQMWSYT FGAWFYKLKR AFFTDSKLKR MLKLTYVDSL
     SITQELLSIS INALEQITIY PMHDNLVSDL EAGLCLLTAF FASYPGTFLT ENIKFVDVIQ
     NLSQIFRYLN TEILATKNAS PQDFYFGFND PDKMKYFIPL CKGRHYAINT FSNHILIKIF
     IKKGVIKQVP GDQMSKGHVV IESKLTGTLT DDKLLYWTQI LLQPKLGKEV PIFVHQQQYL
     RSGIVAIESL YLLWQILNSE SIFGKRTGKF YLTTIFPHVN AEDVTETEFS SVNIQNFEFL
     MKNYVVPTYL ANNESTISTL FPGLISIVVN ESVRLGWDHN QNTLTQTNAL HSQTKDNPFV
     EYIRSQLEET AELAVLEKHD KILFHFENGL NVTLSLALPR HRLFAMASSL FNVADLYDFL
     YFLVLGFIPV ATVI