ID   CVC2_HHV8P              Reviewed;         549 AA.
AC   Q2HRB3;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   02-JUN-2021, entry version 55.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=ORF19;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AF148805; ABD28870.1; -; Genomic_DNA.
DR   RefSeq; YP_001129372.1; NC_009333.1.
DR   PDB; 6PPB; EM; 4.30 A; l/m=1-549.
DR   PDB; 6PPH; EM; 3.80 A; l/m=1-549.
DR   PDBsum; 6PPB; -.
DR   PDBsum; 6PPH; -.
DR   SMR; Q2HRB3; -.
DR   PRIDE; Q2HRB3; -.
DR   DNASU; 4961508; -.
DR   GeneID; 4961508; -.
DR   KEGG; vg:4961508; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Host-virus interaction;
KW   Reference proteome; Viral genome packaging;
KW   Viral penetration into host nucleus; Viral release from host cell; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..549
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000423806"
FT   REGION          1..54
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   549 AA;  61424 MW;  E7A64C2EAE5A7D12 CRC64;
     MLTSERSYLR YPKNRRWTEA GRFWAPHPEN VLFIHKPTME ETRRVALGLR SQLVRNRERK
     TKAHLLSLEL DRLVQVHDSR VRVINADIDA VKQMIGNMTW SDNIDMPQSR SHEPPLVTSP
     PQASHRNFTV AIVPGDPHFS VDRDLRGELM PTLYMNQNQW LPSFGPWFIS LTDNAMQRRV
     FPKELKGTVN FQNSTSLKLI SHTLTTVAST TADFFADARH LTDTQAALCL VNAYFCQKTS
     RQLPATPDDL LADLPQKLDL LITQLKQESG PGDFSFTYSN PQERASLAPL NKESRYPTAF
     FQRHKLHAMM AKAGLFPHNK GTGAPGTAPA MDLVFAITSA MFGSDIPPFS AYQWNLRAGI
     VALEVFILAY GLLEFGQVAR GHPNRRLNLV SLLGPKFQPG ALPDPNAPML KRGQLFSFIS
     EHYIIPTLQA NPNAPVSFIF PGIILAALEA RSTVSHKQPG PFVNLTGSRF NEIFEILNQQ
     LTFRDPLALL QARTALRLAT EEGLDVLLSH PSPPTLLQEI IKSQFGGGDD YDRAYFMVLG
     CLPVVLAVV