ID   CVC2_ILTVT              Reviewed;         572 AA.
AC   P23987;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025};
OS   Infectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid
OS   herpesvirus 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=10344;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2157797; DOI=10.1099/0022-1317-71-4-841;
RA   Griffin A.M., Boursnell M.E.;
RT   "Analysis of the nucleotide sequence of DNA from the region of the
RT   thymidine kinase gene of infectious laryngotracheitis virus; potential
RT   evolutionary relationships between the herpesvirus subfamilies.";
RL   J. Gen. Virol. 71:841-850(1990).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D00565; BAA00440.1; -; Genomic_DNA.
DR   PIR; B43675; B43675.
DR   RefSeq; YP_182354.1; NC_006623.1.
DR   SMR; P23987; -.
DR   PRIDE; P23987; -.
DR   GeneID; 3239021; -.
DR   KEGG; vg:3239021; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..572
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000116004"
FT   REGION          1..58
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   572 AA;  64111 MW;  D040792AD681EE66 CRC64;
     MFRPRFEPMN LPKDSNKPST LMVLADRLNF ISCAEGSSKY ASKLFEGTLI DAEIMTNRAR
     IEDLERRNRA AKAALEQLEN MSATVPVHVS SALQTIEYPL ETVIDVLDDL AQRAVQEKDI
     VGSYKTLDIR APGEDVPANV IWIVKNGEPL TFNTDFQVDF LTTSFAIAGN GRLGFGSWFR
     ALQTQLLDNN KAIARVLNVM GDTRISGRFM KTAIRALRSA MEIYAGTRQY SGFEATVLCL
     LHYSRSRQSA SNIRHGLDVS IFEDALRHVP TYLNYMLEDI RAEWGSVTFS FDRSKLPVNF
     FSPIDGRKYS NGVFDPHIVY QLLKRTGTLS TTVRDITKET LLPIDPDFVR FDDPIAALSI
     SFFPSRRTPL ILHEDDPLVR TVIDSISLLL VLQKLMFNSN VYTSTHLNRF QPSAFFELPL
     GTQSEQEAAK WPVAPGSRPQ ATASTFDDNG QDMASRDNNL FFLFEKYVVP MYRYDNRCEV
     TGFFPGLAAL CITGRVKGIP TAVRLGEYYS SLCNLIELDL RKTSHVGSGA AAVLAVHDSL
     TGDVEEGVSR LLEVFDAKKA FERNIEDIQR GV