ID   CVC2_PSHV1              Reviewed;         627 AA.
AC   Q6UDK7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=UL25;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; AY372243; AAQ73703.1; -; Genomic_DNA.
DR   RefSeq; NP_944397.1; NC_005264.1.
DR   SMR; Q6UDK7; -.
DR   PRIDE; Q6UDK7; -.
DR   GeneID; 2657013; -.
DR   KEGG; vg:2657013; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..627
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000406811"
FT   REGION          1..56
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          458..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   627 AA;  68655 MW;  62907CF6C974D591 CRC64;
     MFGRGLPPLK FGQIGGDGWS TVLADPGNRL IVANAHRSEP RLRVETLIRE ELLTSRARIE
     DLERRNRAAH AALDRLAGKA VAIPLRAAAE LKNVERPLEA AVELLEDMAE RAHHEHEPAV
     VEDERCRKLS AGDQSGQDAG DDDDAGVIRI LKNGSVIPLW KPRTGAKDFH VNFVTMAFAA
     SGDGRVGFGS WYRALQSQLL DSSRGMERIL GVSQDGRVSS RLVRAVIRVL RSAAEIYVGH
     RNYSAFEAAV MCLFQYDAAK RELADAKDGR GSSSGNEPRP ASTFEEAIKL VPHYLRALQE
     DVRREWGAVS YAFDRTKLPQ KFFSPVDAKK YSNGALSPHI VYRLFKARGV FAATGREVTK
     EEIATVDPDF SRFDDPIANL SLAFFPARRS PLSLHEDEPL MRAAIDAVAL MMLLQRLMYN
     SDVYANSMAN RFQAAAFFEG RVTGPVAPAS GDVYGDRLSG DGDPIRAPGS RPPAAAEATL
     SGDGSRDVVS LDNNLVFLFD KYLCPMYRYD NRTEMTGFFP GLAAVCLVGK VRGVPSPSSA
     GDCCSSLINL VDLDLRKTEN TGAGAAVVLT VHDAITYDME TGLSRLLSVF DVKKHMKPVL
     RAMNVETDSD LIYFLCLGCL PHHVTIA