ID   CVC2_SHV21              Reviewed;         543 AA.
AC   Q01004;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   02-JUN-2021, entry version 72.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=19;
OS   Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10383;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA   Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA   Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA   Honess R.W.;
RT   "Primary structure of the herpesvirus saimiri genome.";
RL   J. Virol. 66:5047-5058(1992).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; X64346; CAA45642.1; -; Genomic_DNA.
DR   RefSeq; NP_040221.1; NC_001350.1.
DR   SMR; Q01004; -.
DR   PRIDE; Q01004; -.
DR   GeneID; 1682462; -.
DR   KEGG; vg:1682462; -.
DR   Proteomes; UP000000587; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..543
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000116002"
FT   REGION          1..54
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
FT   REGION          101..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  61485 MW;  19FED18AE852D1E8 CRC64;
     MWKLEKKYIL RQNPSVFLNG TAFWTPHPQN ILHIDRNSLR ETKKNASLYR TRLLNLETEQ
     IKKAMINYEL DKLMQDHVKR SSIITRDLEI IENMVEKFQD SPQLLPSPPK PLSPTTQSQP
     TNFKTNVYTI TVAPGDPGFT VESNFKIELV SSLYTNQQQW LPSYGPWYSS LTDIAMQRRV
     FPKELRGTLN YQNSTSLKLM HAVLTTISSA TDDFYSDVRH ISDTSSALVI LNAYFCLKTS
     APIPVTYEEL LNNLEAKLGM FVFDLKNHTG GNGFSFSPQV NEATSSIAPP NKDTKYSQHF
     FSSHKIYSLL EASGLLSTKS HEINPKTDVI YTITTEIFGE DIPPMASFQW NLRVGIIAIE
     VFVITYLLLE TSQISIHSTH RRLNLSTLLG SKFKKSSTGL LNQIVYKKGQ VFSFLNKNYI
     VPTLTHNKNV PTSFLFPGVT LIALESLATT AVDKPFINLT GNRFQDIFEI INQKFTFKDP
     VSLMAAQTAL RFKVEHGLSN ILTNLSPTTF ATEIIRRQFG GEDDYDTLYF IVLGCLPIAW
     AAV