ID   CVC2_VZVD               Reviewed;         579 AA.
AC   P09287;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   23-FEB-2022, entry version 81.
DE   RecName: Full=Capsid vertex component 2 {ECO:0000255|HAMAP-Rule:MF_04025};
GN   Name=CVC2 {ECO:0000255|HAMAP-Rule:MF_04025}; OrderedLocusNames=34;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Capsid vertex-specific component that plays a role during
CC       viral DNA encapsidation, assuring correct genome cleavage and
CC       presumably stabilizing capsids that contain full-length viral genomes.
CC       Participates in the interaction between the capsid and the tegument
CC       through interaction with the large tegument protein/LTP.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SUBUNIT: Heterodimerizes with CVC1. Interacts with major capsid
CC       protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices.
CC       Interacts with the large tegument protein/LTP. {ECO:0000255|HAMAP-
CC       Rule:MF_04025}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04025}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04025}.
CC   -!- SIMILARITY: Belongs to the herpesviridae CVC2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04025}.
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DR   EMBL; X04370; CAA27917.1; -; Genomic_DNA.
DR   PIR; H27214; WZBE34.
DR   PRIDE; P09287; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
DR   GO; GO:0019072; P:viral genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04025; HSV_CVC2; 1.
DR   InterPro; IPR002493; Herpes_UL25.
DR   Pfam; PF01499; Herpes_UL25; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Host-virus interaction; Reference proteome;
KW   Viral genome packaging; Viral penetration into host nucleus;
KW   Viral release from host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..579
FT                   /note="Capsid vertex component 2"
FT                   /id="PRO_0000116001"
FT   REGION          1..50
FT                   /note="Interaction with major capsid protein/MCP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04025"
SQ   SEQUENCE   579 AA;  65185 MW;  946720E2C40A50DB CRC64;
     MTARYGFGSI SFPNKCGIFL STTKNFIAPN FPIHYWTAPA FELRGRMNPD LEKNTLTLKN
     AAAVAALDNL RGETITLPTE IDRRLKPLEE QLTRMAKVLD SLETAAAEAE EADAQSEECT
     RTEIIRNESI HPEVQIAKND APLQYDTNFQ VDFITLVYLG RARGNNSPGI VFGPWYRTLQ
     ERLVLDRPVA ARGVDCKDGR ISRTFMNTTV TCLQSAGRMY VGDRAYSAFE CAVLCLYLMY
     RTSNSVHEPQ VSSFGNLIEH LPEYTETFVN YMTTHENKNS YQFCYDRLPR DQFHARGGRY
     DQGALTSHSV MDALIRLQVL PPAPGQFNPG VNDIIDRNHT AYVDKIQQAA AAYLERAQNV
     FLMEDQTLLR LTIDTITALL LLRRLLWNGN VYGDKLKNNF QLGLIVSEAT GTPTNNVILR
     GATGFDGKFK SGNNNFQFLC ERYIAPLYTL NRTTELTEMF PGLVALCLDA HTQLSRGSLG
     RTVIDISSGQ YQDRLISLIA LELEHRRQNV TSLPIAAVVS IHDSVMLQYE RGLGMLMHQP
     RVRAALEESR RLAQFNVNSD YDLLYFVCLG VIPQFASTP