ID   CVFA_CONVR              Reviewed;          74 AA.
AC   B3FIA5;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Conotoxin Vi15a;
DE   AltName: Full=Vi15.1;
DE   Flags: Precursor;
OS   Conus virgo (Virgin cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus.
OX   NCBI_TaxID=89427;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 46-72, AMIDATION AT TRP-72,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=18304695; DOI=10.1016/j.peptides.2008.01.007;
RA   Peng C., Liu L., Shao X.X., Chi C.-W., Wang C.G.;
RT   "Identification of a novel class of conotoxins defined as V-conotoxins with
RT   a unique cysteine pattern and signal peptide sequence.";
RL   Peptides 29:985-991(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XV (C-C-CC-C-C-C-C).
CC   -!- PTM: Contains four disulfide bonds.
CC   -!- MASS SPECTROMETRY: Mass=2937.0; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:18304695};
CC   -!- SIMILARITY: Belongs to the conotoxin V superfamily. {ECO:0000305}.
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DR   EMBL; EU169206; ABY26939.1; -; mRNA.
DR   AlphaFoldDB; B3FIA5; -.
DR   SMR; B3FIA5; -.
DR   ConoServer; 2786; ViXVA precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..43
FT                   /id="PRO_0000392196"
FT   PEPTIDE         46..72
FT                   /note="Conotoxin Vi15a"
FT                   /id="PRO_0000392197"
FT   MOD_RES         72
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:18304695"
SQ   SEQUENCE   74 AA;  7887 MW;  B8313B61C66BC762 CRC64;
     MMPVILLLLL SLAIRCADGK AVQGDSDPSA SLLTGDKNHD LPVKRDCTTC AGEECCGRCT
     CPWGDNCSCI EWGK