ID   CVFB_STAA8              Reviewed;         300 AA.
AC   Q2FYP3;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Conserved virulence factor B;
GN   Name=cvfB; OrderedLocusNames=SAOUHSC_01391;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   VIRULENCE FUNCTION IN MURINE MODEL OF SYSTEMIC INFECTION.
RX   PubMed=15576798; DOI=10.1128/jb.186.24.8478-8489.2004;
RA   Benton B.M., Zhang J.P., Bond S., Pope C., Christian T., Lee L.,
RA   Winterberg K.M., Schmid M.B., Buysse J.M.;
RT   "Large-scale identification of genes required for full virulence of
RT   Staphylococcus aureus.";
RL   J. Bacteriol. 186:8478-8489(2004).
RN   [3]
RP   VIRULENCE FUNCTION IN SILKWORM-INFECTION MODEL.
RX   PubMed=15853881; DOI=10.1111/j.1365-2958.2005.04596.x;
RA   Kaito C., Kurokawa K., Matsumoto Y., Terao Y., Kawabata S., Hamada S.,
RA   Sekimizu K.;
RT   "Silkworm pathogenic bacteria infection model for identification of novel
RT   virulence genes.";
RL   Mol. Microbiol. 56:934-944(2005).
RN   [4]
RP   FUNCTION.
RX   PubMed=17283102; DOI=10.1128/iai.01552-06;
RA   Matsumoto Y., Kaito C., Morishita D., Kurokawa K., Sekimizu K.;
RT   "Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB
RT   gene.";
RL   Infect. Immun. 75:1964-1972(2007).
CC   -!- FUNCTION: Contributes to the expression of virulence factors and to
CC       pathogenicity via both agr-dependent and agr-independent pathways.
CC       Involved in the production of hemolysin, DNase, protease and protein A.
CC       Contributes to virulence in silkworm-infection model and murine model
CC       of systemic infection. {ECO:0000269|PubMed:17283102}.
CC   -!- SIMILARITY: Belongs to the CvfB family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD30486.1; -; Genomic_DNA.
DR   RefSeq; WP_001162359.1; NZ_LS483365.1.
DR   RefSeq; YP_499919.1; NC_007795.1.
DR   AlphaFoldDB; Q2FYP3; -.
DR   SMR; Q2FYP3; -.
DR   STRING; 1280.SAXN108_1406; -.
DR   EnsemblBacteria; ABD30486; ABD30486; SAOUHSC_01391.
DR   GeneID; 3920682; -.
DR   KEGG; sao:SAOUHSC_01391; -.
DR   PATRIC; fig|93061.5.peg.1273; -.
DR   eggNOG; COG2996; Bacteria.
DR   HOGENOM; CLU_064885_0_0_9; -.
DR   OMA; GAFMDWG; -.
DR   PHI-base; PHI:2966; -.
DR   PRO; PR:Q2FYP3; -.
DR   Proteomes; UP000008816; Chromosome.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR014464; CvfB_fam.
DR   InterPro; IPR039566; CvfB_S1.
DR   InterPro; IPR040764; CvfB_WH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR37296; PTHR37296; 1.
DR   Pfam; PF17783; CvfB_WH; 1.
DR   Pfam; PF13509; S1_2; 1.
DR   PIRSF; PIRSF012524; YitL_S1; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Virulence.
FT   CHAIN           1..300
FT                   /note="Conserved virulence factor B"
FT                   /id="PRO_0000282296"
SQ   SEQUENCE   300 AA;  34199 MW;  690F0A4784BA9D0C CRC64;
     MALDKDIVGS IEFLEVVGLQ GSTYLLKGPN GENVKLNQSE MNDDDELEVG EEYSFFIYPN
     RSGELFATQN MPDITKDKYD FAKVLKTDRD GARIDVGLPR EVLVPWEDLP KVKSLWPQPG
     DYLLVTLRID RENHMYGRLA SESVVENMFT PVHDDNLKNE VIEAKPYRVL RIGSFLLSES
     GYKIFVHESE RKAEPRLGES VQVRIIGHND KGELNGSFLP LAHERLDDDG QVIFDLLVEY
     DGELPFWDKS SPEAIKEVFN MSKGSFKRAI GHLYKQKIIN IETGKIALTK KGWSRMDSKE