ID   CVFB_STAAN              Reviewed;         300 AA.
AC   Q7A5Q1;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Conserved virulence factor B;
GN   Name=cvfB; OrderedLocusNames=SA1223;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Contributes to the expression of virulence factors and to
CC       pathogenicity. Involved in the production of hemolysin, DNase, protease
CC       and protein A (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CvfB family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB42483.1; -; Genomic_DNA.
DR   PIR; G89915; G89915.
DR   RefSeq; WP_001162352.1; NC_002745.2.
DR   AlphaFoldDB; Q7A5Q1; -.
DR   SMR; Q7A5Q1; -.
DR   EnsemblBacteria; BAB42483; BAB42483; BAB42483.
DR   GeneID; 66839583; -.
DR   KEGG; sau:SA1223; -.
DR   HOGENOM; CLU_064885_0_0_9; -.
DR   OMA; GAFMDWG; -.
DR   Proteomes; UP000000751; Chromosome.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR014464; CvfB_fam.
DR   InterPro; IPR039566; CvfB_S1.
DR   InterPro; IPR040764; CvfB_WH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR37296; PTHR37296; 1.
DR   Pfam; PF17783; CvfB_WH; 1.
DR   Pfam; PF13509; S1_2; 1.
DR   PIRSF; PIRSF012524; YitL_S1; 1.
PE   1: Evidence at protein level;
KW   Virulence.
FT   CHAIN           1..300
FT                   /note="Conserved virulence factor B"
FT                   /id="PRO_0000282295"
SQ   SEQUENCE   300 AA;  34185 MW;  391E06ECE37B90A7 CRC64;
     MALDKDIVGS IEFLEVVGLQ GSTYLLKGPN GENVKLNQSE MNDDDELEVG EEYSFFIYPN
     RSGELFATQN MPDITKDKYD FAKVLKTDRD GARIDVGLPR EVLVPWEDLP KVKSLWPQPG
     DHLLVTLRID RENHMYGRLA SESVVENMFT PVHDDNLKNE VIEAKPYRVL RIGSFLLSES
     GYKIFVHESE RKAEPRLGES VQVRIIGHND KGELNGSFLP LAHERLDDDG QVIFDLLVEY
     DGELPFWDKS SPEAIKEVFN MSKGSFKRAI GHLYKQKIIN IETGKITLTK KGWSRIDSKE