ID   CVFB_STAAR              Reviewed;         300 AA.
AC   Q6GH17;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Conserved virulence factor B;
GN   Name=cvfB; OrderedLocusNames=SAR1403;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Contributes to the expression of virulence factors and to
CC       pathogenicity. Involved in the production of hemolysin, DNase, protease
CC       and protein A (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CvfB family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG40400.1; -; Genomic_DNA.
DR   RefSeq; WP_001162351.1; NC_002952.2.
DR   AlphaFoldDB; Q6GH17; -.
DR   SMR; Q6GH17; -.
DR   KEGG; sar:SAR1403; -.
DR   HOGENOM; CLU_064885_0_0_9; -.
DR   OMA; GAFMDWG; -.
DR   OrthoDB; 1382881at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR014464; CvfB_fam.
DR   InterPro; IPR039566; CvfB_S1.
DR   InterPro; IPR040764; CvfB_WH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR37296; PTHR37296; 1.
DR   Pfam; PF17783; CvfB_WH; 1.
DR   Pfam; PF13509; S1_2; 1.
DR   PIRSF; PIRSF012524; YitL_S1; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..300
FT                   /note="Conserved virulence factor B"
FT                   /id="PRO_0000282291"
SQ   SEQUENCE   300 AA;  34208 MW;  218F8FED537B90A7 CRC64;
     MALDKDIVGS IEFLEVVGLQ GSTYLLKGPN GENVKLNQSE MNDDDELEVG EEYSFFIYPN
     RSGELFATQN MPDITKDKYD FAKVLKTDRD GARIDVGLPR EVLVPWEDLP KVKSLWPQPG
     DHLLVTLRID RENHMYGRLA SESVVENMFT PVHDDNLKNE VIEAKPYRVL RIGSFLLSES
     GYKIFVHESE RKAEPRLGES VQVRIIGHND KGELNGSFLP LAHERLDDDG QVIFDLLVEY
     DGELPFWDKS SPEAIKEVFN MSKGSFKRAI GHLYKHKIIN IETGKITLTK KGWSRIESKE