ID   CVFB_STAAW              Reviewed;         300 AA.
AC   Q8NWS9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Conserved virulence factor B;
GN   Name=cvfB; OrderedLocusNames=MW1279;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Contributes to the expression of virulence factors and to
CC       pathogenicity. Involved in the production of hemolysin, DNase, protease
CC       and protein A (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CvfB family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB95144.1; -; Genomic_DNA.
DR   RefSeq; WP_001162354.1; NC_003923.1.
DR   AlphaFoldDB; Q8NWS9; -.
DR   SMR; Q8NWS9; -.
DR   EnsemblBacteria; BAB95144; BAB95144; BAB95144.
DR   KEGG; sam:MW1279; -.
DR   HOGENOM; CLU_064885_0_0_9; -.
DR   OMA; GAFMDWG; -.
DR   Proteomes; UP000000418; Chromosome.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR014464; CvfB_fam.
DR   InterPro; IPR039566; CvfB_S1.
DR   InterPro; IPR040764; CvfB_WH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR37296; PTHR37296; 1.
DR   Pfam; PF17783; CvfB_WH; 1.
DR   Pfam; PF13509; S1_2; 1.
DR   PIRSF; PIRSF012524; YitL_S1; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..300
FT                   /note="Conserved virulence factor B"
FT                   /id="PRO_0000282294"
SQ   SEQUENCE   300 AA;  34203 MW;  391E06ECE5BB90A7 CRC64;
     MALDKDIVGS IEFLEVVGLQ GSTYLLKGPN GENVKLNQSE MNDDDELEVG EEYSFFIYPN
     RSGELFATQN MPDITKDKYD FAKVLKTDRD GARIDVGLPR EVLVPWEDLP KVKSLWPQPG
     DHLLVTLRID RENHMYGRLA SESVVENMFT PVHDDNLKNE VIEAKPYRVL RIGSFLLSES
     GYKIFVHESE RKAEPRLGES VQVRIIGHND KGELNGSFLP LAHERLDDDG QVIFDLLVEY
     DGELPFWDKS SPEAIKEVFN MSKGSFKRAI GHLYKQKIIN IETGKITLTK KGWSRMDSKE