ID   CVFC_STAA8              Reviewed;         374 AA.
AC   Q2FYK3;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Conserved virulence factor C;
GN   Name=cvfC; OrderedLocusNames=SAOUHSC_01437;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   FUNCTION.
RX   PubMed=15853881; DOI=10.1111/j.1365-2958.2005.04596.x;
RA   Kaito C., Kurokawa K., Matsumoto Y., Terao Y., Kawabata S., Hamada S.,
RA   Sekimizu K.;
RT   "Silkworm pathogenic bacteria infection model for identification of novel
RT   virulence genes.";
RL   Mol. Microbiol. 56:934-944(2005).
CC   -!- FUNCTION: Required for hemolysin production. Contributes to virulence
CC       in both silkworm-infection model and mice.
CC       {ECO:0000269|PubMed:15853881}.
CC   -!- SIMILARITY: Belongs to the CvfC family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD30529.1; -; Genomic_DNA.
DR   RefSeq; WP_000404650.1; NZ_LS483365.1.
DR   RefSeq; YP_499962.1; NC_007795.1.
DR   AlphaFoldDB; Q2FYK3; -.
DR   SMR; Q2FYK3; -.
DR   STRING; 1280.SAXN108_1450; -.
DR   EnsemblBacteria; ABD30529; ABD30529; SAOUHSC_01437.
DR   GeneID; 3920218; -.
DR   KEGG; sao:SAOUHSC_01437; -.
DR   PATRIC; fig|93061.5.peg.1313; -.
DR   eggNOG; COG1413; Bacteria.
DR   HOGENOM; CLU_733295_0_0_9; -.
DR   OMA; VKGVYHV; -.
DR   PRO; PR:Q2FYK3; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.1370.70; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014824; Nfu/NifU_N.
DR   InterPro; IPR036498; Nfu/NifU_N_sf.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   InterPro; IPR025989; Virulence_F_dom.
DR   Pfam; PF08712; Nfu_N; 1.
DR   Pfam; PF13769; Virulence_fact; 1.
DR   SMART; SM00567; EZ_HEAT; 3.
DR   SMART; SM00932; Nfu_N; 1.
DR   SUPFAM; SSF110836; SSF110836; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Virulence.
FT   CHAIN           1..374
FT                   /note="Conserved virulence factor C"
FT                   /id="PRO_0000282309"
SQ   SEQUENCE   374 AA;  42923 MW;  80F8A28D838BFEA6 CRC64;
     MEILRIEPTP SPNTMKVVLS YTREDKLSNT YKKVEETQPR FINQLLSIDG ITSIFHVMNF
     LAVDKAPKAD WEVILPDIKA AFSDANKVLE SVNEPQIDNH FGEIKAELLT FKGIPYQIKL
     TSADQELREQ LPQTYVDHMT QAQTAHDNIV FMRKWLDLGN RYGNIQEVMD GVLEEVLATY
     PESQLPVLVK HALEENHATN NYHFYRHVSL DEYHATDNWK TRLRMLNHFP KPTFEDIPLL
     DLALSDEKVP VRRQAIVLLG MIESKEILPY LYKGLRDKSP AVRRTAGDCI SDLGYPEALP
     EMVLLLDDPQ KIVRWRAAMF IFDEGNAEQL PALKAHINDN AFEVKLQIEM AISRIENGDE
     ALGSVWKQMA NRTI