ID   CVFC_STAAC              Reviewed;         374 AA.
AC   Q5HFZ4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Conserved virulence factor C;
GN   Name=cvfC; OrderedLocusNames=SACOL1465;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Required for hemolysin production. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CvfC family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW36665.1; -; Genomic_DNA.
DR   RefSeq; WP_000404650.1; NC_002951.2.
DR   AlphaFoldDB; Q5HFZ4; -.
DR   SMR; Q5HFZ4; -.
DR   EnsemblBacteria; AAW36665; AAW36665; SACOL1465.
DR   KEGG; sac:SACOL1465; -.
DR   HOGENOM; CLU_733295_0_0_9; -.
DR   OMA; VKGVYHV; -.
DR   PHI-base; PHI:2967; -.
DR   Proteomes; UP000000530; Chromosome.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.1370.70; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014824; Nfu/NifU_N.
DR   InterPro; IPR036498; Nfu/NifU_N_sf.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   InterPro; IPR025989; Virulence_F_dom.
DR   Pfam; PF08712; Nfu_N; 1.
DR   Pfam; PF13769; Virulence_fact; 1.
DR   SMART; SM00567; EZ_HEAT; 3.
DR   SMART; SM00932; Nfu_N; 1.
DR   SUPFAM; SSF110836; SSF110836; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..374
FT                   /note="Conserved virulence factor C"
FT                   /id="PRO_0000282303"
SQ   SEQUENCE   374 AA;  42923 MW;  80F8A28D838BFEA6 CRC64;
     MEILRIEPTP SPNTMKVVLS YTREDKLSNT YKKVEETQPR FINQLLSIDG ITSIFHVMNF
     LAVDKAPKAD WEVILPDIKA AFSDANKVLE SVNEPQIDNH FGEIKAELLT FKGIPYQIKL
     TSADQELREQ LPQTYVDHMT QAQTAHDNIV FMRKWLDLGN RYGNIQEVMD GVLEEVLATY
     PESQLPVLVK HALEENHATN NYHFYRHVSL DEYHATDNWK TRLRMLNHFP KPTFEDIPLL
     DLALSDEKVP VRRQAIVLLG MIESKEILPY LYKGLRDKSP AVRRTAGDCI SDLGYPEALP
     EMVLLLDDPQ KIVRWRAAMF IFDEGNAEQL PALKAHINDN AFEVKLQIEM AISRIENGDE
     ALGSVWKQMA NRTI