ID   CVFC_STAAR              Reviewed;         374 AA.
AC   Q6GGX8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Conserved virulence factor C;
GN   Name=cvfC; OrderedLocusNames=SAR1442;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Required for hemolysin production. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CvfC family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG40439.1; -; Genomic_DNA.
DR   RefSeq; WP_000404628.1; NC_002952.2.
DR   AlphaFoldDB; Q6GGX8; -.
DR   SMR; Q6GGX8; -.
DR   KEGG; sar:SAR1442; -.
DR   HOGENOM; CLU_733295_0_0_9; -.
DR   OMA; VKGVYHV; -.
DR   OrthoDB; 1064510at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.1370.70; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014824; Nfu/NifU_N.
DR   InterPro; IPR036498; Nfu/NifU_N_sf.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   InterPro; IPR025989; Virulence_F_dom.
DR   Pfam; PF08712; Nfu_N; 1.
DR   Pfam; PF13769; Virulence_fact; 1.
DR   SMART; SM00567; EZ_HEAT; 3.
DR   SMART; SM00932; Nfu_N; 1.
DR   SUPFAM; SSF110836; SSF110836; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..374
FT                   /note="Conserved virulence factor C"
FT                   /id="PRO_0000282304"
SQ   SEQUENCE   374 AA;  42971 MW;  8ED94AB44B189BA4 CRC64;
     MEILRIEPTP SPNTMKVVLS YTREDKLSNT YKKVEENQPR FINQLLSIDG ITSIFHVMNF
     LAVDKAPKAD WEDILPDIKA AFSGESQVLE SGKDPQIDNH FGEIKAELLT FKGIPYQIKL
     TSADQELREQ LPQTYVDHMT QAQTKHDNIV FMRKWLDLGN RYGNIEEVMD GVLEEVLATY
     PESQLPVLVK HALEENHATN NYHFYRHVSL DEYHATDNWK TRLRMLNHFP KPTFEDIPLL
     DLALSDEKVP VRRQAIVLLG MIESKEILPY LYKGLRDKSP AVRRTAGDCI SDLGYPEALP
     EMVLLLDDPQ KIVRWRAAMF IFDEGNAEQL PALKAHINDN AFEVKLQIEM AISRIENGDE
     ALGSVWKQMT NRTI