ID   CVFC_STAAS              Reviewed;         374 AA.
AC   Q6G9D2;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Conserved virulence factor C;
GN   Name=cvfC; OrderedLocusNames=SAS1372;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Required for hemolysin production. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CvfC family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG43148.1; -; Genomic_DNA.
DR   RefSeq; WP_000404645.1; NC_002953.3.
DR   AlphaFoldDB; Q6G9D2; -.
DR   SMR; Q6G9D2; -.
DR   KEGG; sas:SAS1372; -.
DR   HOGENOM; CLU_733295_0_0_9; -.
DR   OMA; VKGVYHV; -.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.1370.70; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014824; Nfu/NifU_N.
DR   InterPro; IPR036498; Nfu/NifU_N_sf.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   InterPro; IPR025989; Virulence_F_dom.
DR   Pfam; PF08712; Nfu_N; 1.
DR   Pfam; PF13769; Virulence_fact; 1.
DR   SMART; SM00567; EZ_HEAT; 3.
DR   SMART; SM00932; Nfu_N; 1.
DR   SUPFAM; SSF110836; SSF110836; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..374
FT                   /note="Conserved virulence factor C"
FT                   /id="PRO_0000282305"
SQ   SEQUENCE   374 AA;  42924 MW;  2E2DE3C3595EB07C CRC64;
     MEILRIEPTP SPNTMKVVLS YTREDKLSNT YKKVEETQPR FINQLLSIDG ITSIFHVMNF
     LAVDKAPKAD WEVILPDIKA AFSDANKVLE SVNEPQIDNH FGEIKAELLT FKGIPYQIKL
     TSADQELREQ LPQTYVDHMT QAQTAHDNIV FMRKWLDLGN RYGNIEEVMD GVLEEVLATY
     PESQLPVLVK HALEENHATN NYHFYRHVSL DEYHATDNWK TRLRMLNHFP KPTFEDIPLL
     DLALSDEKVP VRRQAIVLLG MIESKEILPY LYKGLRDKSP AVRRTAGDCI SDLGYPEALP
     EMVLLLDDPQ KIVRWRAAMF IFDEGNAEQL PALKAHINDN AFEVKLQIEM AISRIENGDE
     ALGSVWKQMA NRTI