ID   CVNH_NEUCR              Reviewed;         111 AA.
AC   Q7S6U4;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Cyanovirin-N homolog {ECO:0000303|PubMed:18400178};
DE            Short=CV-N homolog {ECO:0000303|PubMed:18400178};
GN   ORFNames=NCU05495;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2] {ECO:0000305}
RP   STRUCTURE BY NMR, AND FUNCTION.
RX   PubMed=18400178; DOI=10.1016/j.str.2008.01.015;
RA   Koharudin L.M.I., Viscomi A.R., Jee J.-G., Ottonello S., Gronenborn A.M.;
RT   "The evolutionarily conserved family of cyanovirin-N homologs: structures
RT   and carbohydrate specificity.";
RL   Structure 16:570-584(2008).
CC   -!- FUNCTION: Mannose-binding lectin. {ECO:0000269|PubMed:18400178}.
CC   -!- SIMILARITY: Belongs to the cyanovirin-N family. {ECO:0000305}.
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DR   EMBL; CM002241; EAA31221.2; -; Genomic_DNA.
DR   RefSeq; XP_960457.2; XM_955364.3.
DR   PDB; 2JZL; NMR; -; A=1-111.
DR   PDB; 2KJL; NMR; -; A=42-95.
DR   PDB; 3HNU; X-ray; 1.56 A; X=42-95.
DR   PDB; 3HNX; X-ray; 1.37 A; A=42-95.
DR   PDB; 3HP8; X-ray; 2.00 A; A/B=42-95.
DR   PDBsum; 2JZL; -.
DR   PDBsum; 2KJL; -.
DR   PDBsum; 3HNU; -.
DR   PDBsum; 3HNX; -.
DR   PDBsum; 3HP8; -.
DR   AlphaFoldDB; Q7S6U4; -.
DR   SMR; Q7S6U4; -.
DR   UniLectin; Q7S6U4; -.
DR   EnsemblFungi; EAA31221; EAA31221; NCU05495.
DR   GeneID; 3876611; -.
DR   KEGG; ncr:NCU05495; -.
DR   VEuPathDB; FungiDB:NCU05495; -.
DR   HOGENOM; CLU_144945_0_0_1; -.
DR   InParanoid; Q7S6U4; -.
DR   OMA; IGNDNGR; -.
DR   EvolutionaryTrace; Q7S6U4; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.60.10; -; 1.
DR   InterPro; IPR011058; Cyanovirin-N.
DR   InterPro; IPR036673; Cyanovirin-N_sf.
DR   Pfam; PF08881; CVNH; 1.
DR   SMART; SM01111; CVNH; 1.
DR   SUPFAM; SSF51322; SSF51322; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Lectin; Reference proteome.
FT   CHAIN           1..111
FT                   /note="Cyanovirin-N homolog"
FT                   /id="PRO_0000381732"
FT   STRAND          3..5
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   STRAND          11..15
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   STRAND          18..26
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   STRAND          32..38
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   HELIX           39..41
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   STRAND          43..46
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   STRAND          49..52
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   HELIX           57..60
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   STRAND          61..70
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   TURN            71..74
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   STRAND          75..83
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   STRAND          89..95
FT                   /evidence="ECO:0007829|PDB:3HNX"
FT   TURN            97..99
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   STRAND          100..105
FT                   /evidence="ECO:0007829|PDB:2JZL"
FT   STRAND          107..109
FT                   /evidence="ECO:0007829|PDB:2JZL"
SQ   SEQUENCE   111 AA;  12922 MW;  7FB8C455F8BB51FF CRC64;
     MSFHVTAEDA RIEVRDNRTI LFARLRREDG EWNDASYELD QIIGNNDGHF QWGGQNFTET
     AEDIRFHPKE GAAEQPILRA RLRDCNGEFH DRDVNLTEIV ENVNGEFQAK F