ID   CVP3_PIMHY              Reviewed;          63 AA.
AC   Q8T0W3;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Cysteine-rich venom protein 3;
DE            Short=cvp3;
DE   Flags: Precursor;
OS   Pimpla hypochondriaca (Parasitoid wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida;
OC   Ichneumonoidea; Ichneumonidae; Pimplinae; Pimplini; Pimpla.
OX   NCBI_TaxID=135724;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAD27739.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 26-31.
RC   TISSUE=Venom {ECO:0000269|PubMed:15147757}, and
RC   Venom gland {ECO:0000269|PubMed:15147757};
RX   PubMed=15147757; DOI=10.1016/j.ibmb.2004.03.003;
RA   Parkinson N.M., Conyers C., Keen J., MacNicoll A., Smith I., Audsley N.,
RA   Weaver R.;
RT   "Towards a comprehensive view of the primary structure of venom proteins
RT   from the parasitoid wasp Pimpla hypochondriaca.";
RL   Insect Biochem. Mol. Biol. 34:565-571(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15147757}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:15147757}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
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DR   EMBL; AJ438994; CAD27739.1; -; mRNA.
DR   AlphaFoldDB; Q8T0W3; -.
DR   SMR; Q8T0W3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011696; Huwentoxin-1.
DR   Pfam; PF07740; Toxin_12; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:15147757"
FT   CHAIN           26..63
FT                   /note="Cysteine-rich venom protein 3"
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:15147757"
FT                   /id="PRO_0000021048"
FT   DISULFID        29..43
FT                   /evidence="ECO:0000250|UniProtKB:P56207"
FT   DISULFID        36..48
FT                   /evidence="ECO:0000250|UniProtKB:P56207"
FT   DISULFID        42..58
FT                   /evidence="ECO:0000250|UniProtKB:P56207"
SQ   SEQUENCE   63 AA;  6869 MW;  5BBDD96CF024FEDF CRC64;
     MRKPITLILV VALALVLLAT SEVSAYRACG FPGRRCSPTE ECCEGLVCQP RKNGPSMCYR
     PDP