ID   CVP5_PIMHY              Reviewed;         115 AA.
AC   Q8T0W1;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Cysteine-rich venom protein 5;
DE            Short=cvp5;
DE   Flags: Precursor;
OS   Pimpla hypochondriaca (Parasitoid wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida;
OC   Ichneumonoidea; Ichneumonidae; Pimplinae; Pimplini; Pimpla.
OX   NCBI_TaxID=135724;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAD27741.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 23-27.
RC   TISSUE=Venom {ECO:0000269|PubMed:15147757}, and
RC   Venom gland {ECO:0000269|PubMed:15147757};
RX   PubMed=15147757; DOI=10.1016/j.ibmb.2004.03.003;
RA   Parkinson N.M., Conyers C., Keen J., MacNicoll A., Smith I., Audsley N.,
RA   Weaver R.;
RT   "Towards a comprehensive view of the primary structure of venom proteins
RT   from the parasitoid wasp Pimpla hypochondriaca.";
RL   Insect Biochem. Mol. Biol. 34:565-571(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15147757}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:15147757}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
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DR   EMBL; AJ438996; CAD27741.1; -; mRNA.
DR   AlphaFoldDB; Q8T0W1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:15147757"
FT   CHAIN           23..115
FT                   /note="Cysteine-rich venom protein 5"
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:15147757"
FT                   /id="PRO_0000021049"
FT   REGION          54..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..115
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        26..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        33..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..51
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  12678 MW;  4AB954F302C60118 CRC64;
     MSKVMIIMLV GMIFAIISTV SGGAGCSSMG ASCQIGSATC CGVCNVHTLR CEARIGPPIN
     TQPTRRTQPT RRTRGPKVTR SSRPTNRTRR PKPTNRSRRP KPTHRRKPTN RPRSH