CVP6_PIMHY
ID CVP6_PIMHY Reviewed; 77 AA.
AC Q8T0W0;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Cysteine-rich venom protein 6;
DE Short=cvp6;
DE Flags: Precursor;
OS Pimpla hypochondriaca (Parasitoid wasp).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida;
OC Ichneumonoidea; Ichneumonidae; Pimplinae; Pimplini; Pimpla.
OX NCBI_TaxID=135724;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 22-27.
RC TISSUE=Venom, and Venom gland;
RX PubMed=15147757; DOI=10.1016/j.ibmb.2004.03.003;
RA Parkinson N.M., Conyers C., Keen J., MacNicoll A., Smith I., Audsley N.,
RA Weaver R.;
RT "Towards a comprehensive view of the primary structure of venom proteins
RT from the parasitoid wasp Pimpla hypochondriaca.";
RL Insect Biochem. Mol. Biol. 34:565-571(2004).
CC -!- FUNCTION: May be a phenoloxidase inhibitor that stabilizes or inhibits
CC venom phenoloxidase while it is stored in the venom sac. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the serine protease inhibitor-like (TIL domain-
CC containing) family. {ECO:0000305}.
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DR EMBL; AJ438997; CAD27742.1; -; mRNA.
DR AlphaFoldDB; Q8T0W0; -.
DR SMR; Q8T0W0; -.
DR MEROPS; I08.954; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR Pfam; PF01826; TIL; 1.
DR SUPFAM; SSF57567; SSF57567; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000269|PubMed:15147757"
FT CHAIN 22..77
FT /note="Cysteine-rich venom protein 6"
FT /id="PRO_0000034312"
FT DOMAIN 24..76
FT /note="TIL"
FT DISULFID 24..56
FT /evidence="ECO:0000250"
FT DISULFID 33..52
FT /evidence="ECO:0000250"
FT DISULFID 37..48
FT /evidence="ECO:0000250"
FT DISULFID 41..76
FT /evidence="ECO:0000250"
FT DISULFID 58..70
FT /evidence="ECO:0000250"
SQ SEQUENCE 77 AA; 8184 MW; 6889CB5F40D63DD6 CRC64;
MSRYALIVLI VVVVAANLCE ASDCGPNRVY KSCGTGCPET CENPDPDCDR ACHQGCFCSK
GLLQDIDGNC ISPDKCP