CW15A_XENLA
ID CW15A_XENLA Reviewed; 228 AA.
AC Q6NUB2;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Protein CWC15 homolog A;
GN Name=cwc15-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC spliceosome. {ECO:0000250|UniProtKB:Q9P013}.
CC -!- SUBUNIT: Identified in the spliceosome C complex.
CC {ECO:0000250|UniProtKB:Q9P013}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P013}.
CC -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR EMBL; BC068684; AAH68684.1; -; mRNA.
DR RefSeq; NP_001084754.1; NM_001091285.1.
DR AlphaFoldDB; Q6NUB2; -.
DR DNASU; 414727; -.
DR GeneID; 414727; -.
DR KEGG; xla:414727; -.
DR CTD; 414727; -.
DR Xenbase; XB-GENE-987023; cwc15.S.
DR OMA; NCARSEP; -.
DR OrthoDB; 1576404at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 414727; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR InterPro; IPR006973; Cwf_Cwc_15.
DR PANTHER; PTHR12718; PTHR12718; 1.
DR Pfam; PF04889; Cwf_Cwc_15; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..228
FT /note="Protein CWC15 homolog A"
FT /id="PRO_0000291548"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..165
FT /evidence="ECO:0000255"
FT COMPBIAS 35..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 228 AA; 26338 MW; C36562B441C5237D CRC64;
MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQATQDA PEEVRSRDFR
RELEERERVV ARDKNRDRPT REHTSSVSKK PRLDQIPAAN LDADDPLTDE DGDEDSDEDS
DDDTAALLAE LEKIKKERAE EKDRKELEQK AEEERIRMEN ILSGNPLLNL TGPAAQSQAS
FKVKRRWDDD VVFKNCAKGV DEMKKQKRFV NDTLRSEFHK KFMEKYIK