ID   CWC15_BOVIN             Reviewed;         231 AA.
AC   Q2KJD3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Spliceosome-associated protein CWC15 homolog;
GN   Name=CWC15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. Component of the PRP19-CDC5L complex that forms an
CC       integral part of the spliceosome and is required for activating pre-
CC       mRNA splicing. {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Component of the
CC       PRP19-CDC5L splicing complex composed of a core complex comprising a
CC       homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less
CC       stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly
CC       with CTNNBL1 in the complex. {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR   EMBL; BC105398; AAI05399.1; -; mRNA.
DR   RefSeq; NP_001039864.1; NM_001046399.2.
DR   RefSeq; XP_005215821.1; XM_005215764.1.
DR   RefSeq; XP_005215822.1; XM_005215765.3.
DR   AlphaFoldDB; Q2KJD3; -.
DR   SMR; Q2KJD3; -.
DR   STRING; 9913.ENSBTAP00000010403; -.
DR   PaxDb; Q2KJD3; -.
DR   PRIDE; Q2KJD3; -.
DR   Ensembl; ENSBTAT00000010403; ENSBTAP00000010403; ENSBTAG00000007913.
DR   GeneID; 535258; -.
DR   KEGG; bta:535258; -.
DR   CTD; 51503; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007913; -.
DR   VGNC; VGNC:54863; CWC15.
DR   eggNOG; KOG3228; Eukaryota.
DR   GeneTree; ENSGT00390000012084; -.
DR   HOGENOM; CLU_068312_0_1_1; -.
DR   InParanoid; Q2KJD3; -.
DR   OMA; NCARSEP; -.
DR   OrthoDB; 1576404at2759; -.
DR   TreeFam; TF321323; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000007913; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000974; C:Prp19 complex; IEA:Ensembl.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR006973; Cwf_Cwc_15.
DR   PANTHER; PTHR12718; PTHR12718; 1.
DR   Pfam; PF04889; Cwf_Cwc_15; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; mRNA processing; mRNA splicing; Nucleus;
KW   Phosphoprotein; Reference proteome; Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   CHAIN           2..231
FT                   /note="Spliceosome-associated protein CWC15 homolog"
FT                   /id="PRO_0000291542"
FT   REGION          1..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          125..167
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        35..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..129
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   MOD_RES         18
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHS9"
FT   MOD_RES         47
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   MOD_RES         110
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
SQ   SEQUENCE   231 AA;  26869 MW;  84C4FD86AF05BEB8 CRC64;
     MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR
     RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA ANLDADDPLT DEEDEDEDFE
     EESDDDDTAA LLAELEKIKK ERAEEQARKE QEQKAEEERI RMENILSGNP LLNLTGPSQP
     QANFKVKRRW DDDVVFKNCA KGVDDQKKDK RFVNDTLRSE FHKKFMEKYI K