CWC15_CAEEL
ID CWC15_CAEEL Reviewed; 230 AA.
AC O45766;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Spliceosome-associated protein CWC15 homolog {ECO:0000305};
GN Name=cwc-15 {ECO:0000312|WormBase:T10C6.5};
GN ORFNames=T10C6.5 {ECO:0000312|WormBase:T10C6.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of a spliceosomal complex that is required for
CC activating pre-mRNA splicing. {ECO:0000250|UniProtKB:Q9P013}.
CC -!- SUBUNIT: Component of spliceosomal complex.
CC {ECO:0000250|UniProtKB:Q9P013}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P013}.
CC -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR EMBL; Z93388; CAB07655.1; -; Genomic_DNA.
DR PIR; T24789; T24789.
DR RefSeq; NP_507024.1; NM_074623.4.
DR AlphaFoldDB; O45766; -.
DR BioGRID; 45060; 4.
DR DIP; DIP-26099N; -.
DR IntAct; O45766; 2.
DR STRING; 6239.T10C6.5; -.
DR EPD; O45766; -.
DR PaxDb; O45766; -.
DR PeptideAtlas; O45766; -.
DR PRIDE; O45766; -.
DR EnsemblMetazoa; T10C6.5.1; T10C6.5.1; WBGene00011687.
DR GeneID; 180069; -.
DR KEGG; cel:CELE_T10C6.5; -.
DR UCSC; T10C6.5; c. elegans.
DR CTD; 180069; -.
DR WormBase; T10C6.5; CE16380; WBGene00011687; cwc-15.
DR eggNOG; KOG3228; Eukaryota.
DR GeneTree; ENSGT00390000012084; -.
DR HOGENOM; CLU_068312_0_1_1; -.
DR InParanoid; O45766; -.
DR OMA; NCARSEP; -.
DR OrthoDB; 1576404at2759; -.
DR PhylomeDB; O45766; -.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:O45766; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011687; Expressed in embryo and 4 other tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:WormBase.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR InterPro; IPR006973; Cwf_Cwc_15.
DR PANTHER; PTHR12718; PTHR12718; 1.
DR Pfam; PF04889; Cwf_Cwc_15; 1.
PE 3: Inferred from homology;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..230
FT /note="Spliceosome-associated protein CWC15 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000291551"
FT REGION 1..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 47..82
FT /evidence="ECO:0000255"
FT COILED 119..164
FT /evidence="ECO:0000255"
FT COMPBIAS 22..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..126
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 230 AA; 26105 MW; 31E490275CF5682F CRC64;
MTTAHRPTFH PARGGTARGE GDLSKLSNQY SSKDMPSHTK MKYRQTGQET EADLRKKDLR
RELEDKERNA IREKRARDSA SSSSSHSKRQ RMDQIAAESA ASVDADEAVD ELNSSDDDDS
DEDDTAALMA ELEKIKKERA EEKAARDEEI KEKEEKQRME NILAGNPLLN DTPAGSSTSG
GDFTVKRRWD DDVVFKNCAK GVEERKKEVT FINDAIRSEF HKKFMDKYIK
