ID   CWC15_DANRE             Reviewed;         243 AA.
AC   Q6IQU4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Protein CWC15 homolog;
GN   Name=cwc15; ORFNames=zgc:86607;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex.
CC       {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR   EMBL; BC071310; AAH71310.1; -; mRNA.
DR   AlphaFoldDB; Q6IQU4; -.
DR   STRING; 7955.ENSDARP00000022647; -.
DR   PaxDb; Q6IQU4; -.
DR   PeptideAtlas; Q6IQU4; -.
DR   PRIDE; Q6IQU4; -.
DR   ZFIN; ZDB-GENE-040625-10; cwc15.
DR   eggNOG; KOG3228; Eukaryota.
DR   InParanoid; Q6IQU4; -.
DR   Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q6IQU4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR006973; Cwf_Cwc_15.
DR   PANTHER; PTHR12718; PTHR12718; 1.
DR   Pfam; PF04889; Cwf_Cwc_15; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..243
FT                   /note="Protein CWC15 homolog"
FT                   /id="PRO_0000291547"
FT   REGION          1..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          127..169
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        35..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..131
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  27804 MW;  4305C317C1494F8F CRC64;
     MTTAARPTFE PARGGRGKGE GDLSALSKQY SSRDLPGHTK IKYRQPTQDA PEEVRARDFR
     RELEERERAA VKGRDRGARE HTTSSSSSSS SSSSKRPRLD QIPAANLDAD DPLTDDEDDS
     GSDSDSDDDT AALLAELEKI KRERAEEQER KEREQKAEEE RIRMENILSG NPLLNLAGQQ
     QQQQQQQQQT QTKNTFSVKR RWDDDVVFKN CAKGVDESRK EKRFVNDTLR SEFHKKFMEK
     YVK