ID   CWC15_KLULA             Reviewed;         187 AA.
AC   Q6CQI2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Pre-mRNA-splicing factor CWC15;
GN   Name=CWC15; OrderedLocusNames=KLLA0D16896g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00903.1; -; Genomic_DNA.
DR   RefSeq; XP_453807.1; XM_453807.1.
DR   AlphaFoldDB; Q6CQI2; -.
DR   STRING; 28985.XP_453807.1; -.
DR   EnsemblFungi; CAH00903; CAH00903; KLLA0_D16896g.
DR   GeneID; 2892823; -.
DR   KEGG; kla:KLLA0_D16896g; -.
DR   eggNOG; KOG3228; Eukaryota.
DR   HOGENOM; CLU_100667_0_0_1; -.
DR   InParanoid; Q6CQI2; -.
DR   OMA; NCARSEP; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR006973; Cwf_Cwc_15.
DR   PANTHER; PTHR12718; PTHR12718; 2.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..187
FT                   /note="Pre-mRNA-splicing factor CWC15"
FT                   /id="PRO_0000218241"
FT   REGION          33..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          72..131
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        46..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..99
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   187 AA;  21647 MW;  B72C3C0238A81156 CRC64;
     MTTSHRPQLE ARNGAKNIEY IPTSTQHARL LPGHKEVKYR NTKKRVLNRK VESTPSEEAK
     KRIKITGAEE CSKDEEIQAT DSSDEYEEEE EESEDEEALL EEWNKVKQER LDKKLREQRA
     EITAAQNEEV TKPQKHGGWR SNTVFGRKGT VNQSASISEH NSNGKGKYVN NITQSEYHKE
     FIRKHVK