ID   CWC15_PONAB             Reviewed;         229 AA.
AC   Q5RE65;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Spliceosome-associated protein CWC15 homolog;
GN   Name=CWC15;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. Component of the PRP19-CDC5L complex that forms an
CC       integral part of the spliceosome and is required for activating pre-
CC       mRNA splicing. {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Component of the
CC       PRP19-CDC5L splicing complex composed of a core complex comprising a
CC       homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less
CC       stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly
CC       with CTNNBL1 in the complex. {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P013}.
CC   -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR   EMBL; CR857672; CAH89942.1; -; mRNA.
DR   RefSeq; NP_001127215.1; NM_001133743.1.
DR   AlphaFoldDB; Q5RE65; -.
DR   SMR; Q5RE65; -.
DR   STRING; 9601.ENSPPYP00000004330; -.
DR   Ensembl; ENSPPYT00000004504; ENSPPYP00000004330; ENSPPYG00000003785.
DR   GeneID; 100174270; -.
DR   KEGG; pon:100174270; -.
DR   CTD; 51503; -.
DR   eggNOG; KOG3228; Eukaryota.
DR   GeneTree; ENSGT00390000012084; -.
DR   HOGENOM; CLU_068312_0_1_1; -.
DR   InParanoid; Q5RE65; -.
DR   OMA; NCARSEP; -.
DR   OrthoDB; 1576404at2759; -.
DR   TreeFam; TF321323; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000974; C:Prp19 complex; IEA:Ensembl.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR006973; Cwf_Cwc_15.
DR   PANTHER; PTHR12718; PTHR12718; 1.
DR   Pfam; PF04889; Cwf_Cwc_15; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; mRNA processing; mRNA splicing; Nucleus;
KW   Phosphoprotein; Reference proteome; Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   CHAIN           2..229
FT                   /note="Spliceosome-associated protein CWC15 homolog"
FT                   /id="PRO_0000291545"
FT   REGION          1..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          123..165
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        35..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..127
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   MOD_RES         18
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHS9"
FT   MOD_RES         47
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   MOD_RES         110
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
FT   MOD_RES         121
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P013"
SQ   SEQUENCE   229 AA;  26624 MW;  B21E6EEF46C4427C CRC64;
     MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR
     RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA ANLDADDPLT DEEDEDFEEE
     SDDDDTAALL AELEKIKKER AEEQARKEQE QKAEEERIRM ENILSGNPLL NLTGPSQPQA
     NFKVKRRWDD DVVFKNCAKG VDDQKKDKRF VNDTLRSEFH KKFMEKYIK