CWC15_YARLI
ID CWC15_YARLI Reviewed; 215 AA.
AC Q6C0E6;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Pre-mRNA-splicing factor CWC15;
GN Name=CWC15; OrderedLocusNames=YALI0F25421g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CWC15 family. {ECO:0000305}.
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DR EMBL; CR382132; CAG78677.1; -; Genomic_DNA.
DR RefSeq; XP_505866.1; XM_505866.1.
DR AlphaFoldDB; Q6C0E6; -.
DR STRING; 4952.CAG78677; -.
DR EnsemblFungi; CAG78677; CAG78677; YALI0_F25421g.
DR GeneID; 2908528; -.
DR KEGG; yli:YALI0F25421g; -.
DR VEuPathDB; FungiDB:YALI0_F25421g; -.
DR HOGENOM; CLU_068312_0_1_1; -.
DR InParanoid; Q6C0E6; -.
DR OMA; KGYEDRD; -.
DR Proteomes; UP000001300; Chromosome F.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR InterPro; IPR006973; Cwf_Cwc_15.
DR PANTHER; PTHR12718; PTHR12718; 1.
DR Pfam; PF04889; Cwf_Cwc_15; 1.
PE 3: Inferred from homology;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..215
FT /note="Pre-mRNA-splicing factor CWC15"
FT /id="PRO_0000218243"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..162
FT /evidence="ECO:0000255"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 24732 MW; 5A4D2137B8B6A59D CRC64;
MTTAHRPTFD PARGKSNTQA AGSISHTRSL PSHTKLKYRY ARISTNTDAM RKTLLENEGG
LKQAATKLVA EQQQAETQVQ DSEKELSDEV KAKIIEENRD DDDSGSDDEE SDSDDSDSDS
DDEDELLRIE LERIKQERAQ AKAREEERLA LEEAKAREEQ VAFGNPLMNP VAIKRKWNED
VVFRNQTKQA RKEDSYVNDL IRSDFHRKFM NRYVR