CWC21_ASHGO
ID CWC21_ASHGO Reviewed; 125 AA.
AC Q751G9;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Pre-mRNA-splicing factor CWC21;
GN Name=CWC21; OrderedLocusNames=AGL263W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in pre-mRNA splicing. May function at or prior to
CC the first catalytic step of splicing at the catalytic center of the
CC spliceosome. May do so by stabilizing the catalytic center or the
CC position of the RNA substrate (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the NTC complex (or PRP19-associated complex).
CC The NTC complex associates with the spliceosome after the release of
CC the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex
CC reminiscent of a late-stage spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54228.1; -; Genomic_DNA.
DR RefSeq; NP_986404.1; NM_211466.1.
DR AlphaFoldDB; Q751G9; -.
DR SMR; Q751G9; -.
DR STRING; 33169.AAS54228; -.
DR EnsemblFungi; AAS54228; AAS54228; AGOS_AGL263W.
DR GeneID; 4622697; -.
DR KEGG; ago:AGOS_AGL263W; -.
DR eggNOG; KOG1869; Eukaryota.
DR HOGENOM; CLU_067891_3_1_1; -.
DR InParanoid; Q751G9; -.
DR OMA; ISKPGHY; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR Pfam; PF08312; cwf21; 1.
DR SMART; SM01115; cwf21; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Spliceosome.
FT CHAIN 1..125
FT /note="Pre-mRNA-splicing factor CWC21"
FT /id="PRO_0000123493"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 59..114
FT /evidence="ECO:0000255"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 125 AA; 13887 MW; EEBCA8E8639A6E8F CRC64;
MSYNGIGLKT AKGSSTSGHI QRSLADNQAG NVKNFSSRKE ESQGRVARAS RERKLDGSMA
AHADRREIEV RVSELRDELE DADIDAEEIE RRCEQLRRQL QSEAAERARV AQAYTPRNAR
SAGAT
