ID   CWC21_ASPFU             Reviewed;         217 AA.
AC   Q4WDD0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pre-mRNA-splicing factor cwc21;
GN   Name=cwc21; ORFNames=AFUA_6G04320;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. May function at or prior to
CC       the first catalytic step of splicing at the catalytic center of the
CC       spliceosome. May do so by stabilizing the catalytic center or the
CC       position of the RNA substrate (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the NTC complex (or PRP19-associated complex).
CC       The NTC complex associates with the spliceosome after the release of
CC       the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex
CC       reminiscent of a late-stage spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
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DR   EMBL; AAHF01000012; EAL85608.1; -; Genomic_DNA.
DR   RefSeq; XP_747646.1; XM_742553.1.
DR   AlphaFoldDB; Q4WDD0; -.
DR   SMR; Q4WDD0; -.
DR   STRING; 746128.CADAFUBP00009134; -.
DR   EnsemblFungi; EAL85608; EAL85608; AFUA_6G04320.
DR   GeneID; 3505320; -.
DR   KEGG; afm:AFUA_6G04320; -.
DR   VEuPathDB; FungiDB:Afu6g04320; -.
DR   eggNOG; KOG1869; Eukaryota.
DR   HOGENOM; CLU_067891_2_0_1; -.
DR   InParanoid; Q4WDD0; -.
DR   OMA; LAHMRPR; -.
DR   OrthoDB; 1614776at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR   Pfam; PF08312; cwf21; 1.
DR   SMART; SM01115; cwf21; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..217
FT                   /note="Pre-mRNA-splicing factor cwc21"
FT                   /id="PRO_0000123494"
FT   REGION          30..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          65..135
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        52..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  25287 MW;  114D3319ED6EBD08 CRC64;
     MSSNVGLSTP RGSGTSGYVQ RNYAFMKPRN AGYGAPYPPV SGANANDSSR GFKQRQPDKQ
     ILEHDRRRAV EVKVMEERER LEEENERIEQ EGKGKGEGEG KVLSEEEIEE RCEALRARLL
     KEMEEEENRK GDAADGERDE GRERRGWKRG PRDRERDLPP RERRQFKTYQ VHELAEAKIE
     ESERFKKALG IREDTETGEI SSGRKDYEPR KRDRERY