CWC21_CANAL
ID CWC21_CANAL Reviewed; 162 AA.
AC Q5AP89; A0A1D8PER7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Pre-mRNA-splicing factor CWC21;
GN Name=CWC21; OrderedLocusNames=CAALFM_C110080WA;
GN ORFNames=CaO19.12339, CaO19.4875;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in pre-mRNA splicing. May function at or prior to
CC the first catalytic step of splicing at the catalytic center of the
CC spliceosome. May do so by stabilizing the catalytic center or the
CC position of the RNA substrate (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with the NTC complex (or PRP19-associated complex).
CC The NTC complex associates with the spliceosome after the release of
CC the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex
CC reminiscent of a late-stage spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26639.1; -; Genomic_DNA.
DR RefSeq; XP_723559.2; XM_718466.2.
DR AlphaFoldDB; Q5AP89; -.
DR SMR; Q5AP89; -.
DR STRING; 237561.Q5AP89; -.
DR PRIDE; Q5AP89; -.
DR GeneID; 3634814; -.
DR KEGG; cal:CAALFM_C110080WA; -.
DR CGD; CAL0000190345; orf19.12339.
DR VEuPathDB; FungiDB:C1_10080W_A; -.
DR eggNOG; KOG1869; Eukaryota.
DR HOGENOM; CLU_067891_3_0_1; -.
DR InParanoid; Q5AP89; -.
DR OrthoDB; 1614776at2759; -.
DR PRO; PR:Q5AP89; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR Pfam; PF08312; cwf21; 1.
DR SMART; SM01115; cwf21; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Spliceosome.
FT CHAIN 1..162
FT /note="Pre-mRNA-splicing factor CWC21"
FT /id="PRO_0000123495"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 48..150
FT /evidence="ECO:0000255"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 162 AA; 18880 MW; 9BA25FFB78F78970 CRC64;
MSYNGIGLQS VRGSATSGHI QKNIANKISK PGHYESRKNQ KSLMSKRADE AKQSQNKREA
YKQIKSELTK HEQLRRIEVK CMDLQDELEE QGVEPDEIKA RVDELRKKLN NKEFDENDAK
SPTTTTPQPS RKDKQLKEDL ENENKNKDGV FEYKRRYADK RN
