ID   CWC21_YARLI             Reviewed;         284 AA.
AC   Q6C0M9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Pre-mRNA-splicing factor CWC21;
GN   Name=CWC21; OrderedLocusNames=YALI0F23309g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. May function at or prior to
CC       the first catalytic step of splicing at the catalytic center of the
CC       spliceosome. May do so by stabilizing the catalytic center or the
CC       position of the RNA substrate (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the NTC complex (or PRP19-associated complex).
CC       The NTC complex associates with the spliceosome after the release of
CC       the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex
CC       reminiscent of a late-stage spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78594.1; -; Genomic_DNA.
DR   RefSeq; XP_505783.1; XM_505783.1.
DR   AlphaFoldDB; Q6C0M9; -.
DR   SMR; Q6C0M9; -.
DR   STRING; 4952.CAG78594; -.
DR   EnsemblFungi; CAG78594; CAG78594; YALI0_F23309g.
DR   GeneID; 2908777; -.
DR   KEGG; yli:YALI0F23309g; -.
DR   VEuPathDB; FungiDB:YALI0_F23309g; -.
DR   HOGENOM; CLU_980723_0_0_1; -.
DR   InParanoid; Q6C0M9; -.
DR   OMA; RDYQEGS; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR013170; mRNA_splic_Cwf21_dom.
DR   Pfam; PF08312; cwf21; 1.
DR   SMART; SM01115; cwf21; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..284
FT                   /note="Pre-mRNA-splicing factor CWC21"
FT                   /id="PRO_0000123504"
FT   REGION          148..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          71..118
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        148..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   284 AA;  33651 MW;  11D3454B49EC12DA CRC64;
     MSYNGIGLST PRGSATSGHI QTNISNRAFQ STNHRGEFAH HEMTDEQDKR LNKKLDRDYA
     ADRQADVELL EHERKRKVEV ACMELQDKLE EEGQKGEEEI EEEVNTLRRQ LTLKMARELD
     VRTTIVSADR EALRKNYHKA AVIKQQEMDR MRDAFDTTKN LDDRGRDRPR NRQRQNREKS
     PVRDTRRSRS ARERSPSRRG RRPRRYSVTE DVRTSEVISE RQGSGSPCRR ADSRSRSRSP
     ERGSRRKSYR ERSRSRSRER SERRGRRDSV REREQDRSRS PLPY