ID   CWC22_ASHGO             Reviewed;         554 AA.
AC   Q751P4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Pre-mRNA-splicing factor CWC22;
GN   Name=CWC22; OrderedLocusNames=AGL355W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May be involved in pre-mRNA splicing.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54136.1; -; Genomic_DNA.
DR   RefSeq; NP_986312.1; NM_211374.1.
DR   AlphaFoldDB; Q751P4; -.
DR   SMR; Q751P4; -.
DR   STRING; 33169.AAS54136; -.
DR   EnsemblFungi; AAS54136; AAS54136; AGOS_AGL355W.
DR   GeneID; 4622605; -.
DR   KEGG; ago:AGOS_AGL355W; -.
DR   eggNOG; KOG2140; Eukaryota.
DR   HOGENOM; CLU_006308_3_3_1; -.
DR   InParanoid; Q751P4; -.
DR   OMA; NIFKFDA; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   Pfam; PF02847; MA3; 1.
DR   SMART; SM00544; MA3; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..554
FT                   /note="Pre-mRNA-splicing factor CWC22"
FT                   /id="PRO_0000215667"
FT   DOMAIN          14..196
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   DOMAIN          280..396
FT                   /note="MI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   REGION          473..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..544
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  63162 MW;  335C010C1C6E0B74 CRC64;
     MDEELQLKNW TELHNHIKSV LDRLDESRIN ESFQELLEVN VIRGRGILAS EVVREERVVR
     QGAVLGALVE LFEDYIPELG IMVSREALLL FLKSFRGGRT KYCYGLLALL CQLCNSDVMH
     EIGLLQLADL LLEVPRDRAV GMLCFMLGQA GAHLMNVCRT AHDQLLARLT DMLHDGKLSP
     TSSNRIQELL RLRRSNYKGQ ATKFSLPDHG VCTHRVTLEL DIPARLEPDS SLGKFYVDNQ
     FFDTEERFAA LRRQALERFL GQQQQQAEPV KDMTNAEEVQ YKKQIYLILK GSLTGDEAAH
     KLLKLRPDAS QKATIVEIVV KACAQEQTYT KFYGILAERL CGSHRNWPTS FTNLFRDLYG
     TLHEFEPNQL RNMGKFWGHM LAADHIGLNL FECVHLSEHR TTPSSRVFLK FIFQELVADL
     GIAEVRKRLE DENAQPLVQG LFPKEGNADT VFAINYFTAI GLGVLTESMR TSLPTQAKSD
     SGNMSPNGQT LSYPSSRVPR RTRSRSPPRT RVRGDSPQRA RVEQRYSRYD PGPAHRDRRR
     SRLSVTPPPR RNIH