CWC22_ASPFU
ID CWC22_ASPFU Reviewed; 881 AA.
AC Q4WKB9;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Pre-mRNA-splicing factor cwc22;
GN Name=cwc22; ORFNames=AFUA_1G03010;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR EMBL; AAHF01000007; EAL88013.1; -; Genomic_DNA.
DR RefSeq; XP_750051.1; XM_744958.1.
DR AlphaFoldDB; Q4WKB9; -.
DR SMR; Q4WKB9; -.
DR STRING; 746128.CADAFUBP00000333; -.
DR EnsemblFungi; EAL88013; EAL88013; AFUA_1G03010.
DR GeneID; 3507791; -.
DR KEGG; afm:AFUA_1G03010; -.
DR VEuPathDB; FungiDB:Afu1g03010; -.
DR eggNOG; KOG2140; Eukaryota.
DR HOGENOM; CLU_006308_0_2_1; -.
DR InParanoid; Q4WKB9; -.
DR OMA; NIFKFDA; -.
DR OrthoDB; 996017at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02847; MA3; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..881
FT /note="Pre-mRNA-splicing factor cwc22"
FT /id="PRO_0000215668"
FT DOMAIN 145..328
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 427..543
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..98
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..414
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 100843 MW; 79FD552D50E01424 CRC64;
MTDSVVLQSA VRVPTPPPGT SYSPQPSVSR KRSPPSRSPS PRRRRSPPGD SLKENGDAPR
IDPERAVERE RQLAERLRQH EKREAARKPM TEEEKQAAAK AEYEKLLNMR SGGTYIPPAR
LRALQAQITD KNSKEYQRMA WEALKKSING LINKVNVSNI KFIVPELFGE NLVRGRGLFC
RSIMKAQAAS LPFTPIYAAM AAIVNTKLPQ VGELLLNRLI VQFRKAFKRN DKAVCISSTT
FIAHLCNQQV AHEMLAAQIL LLLLHKPTDD SVEIAVGLTR EVGQHLEEMS PPIALAVFDQ
FRNILHEADI DKRVQYMIEV LFQVRKDRYK DNPAIKDELD LVEEEDQITH RIGLDDEIDT
QDGLNVFKYD PQWEEHEEAY KKLKAEILGE GSDDDEEDED ETDESSDEEE EERQMEIKDQ
SNTDLVNLRR TIYLTIMSSI DFEECCHKLM KISLPPGLEP ELPSMIIECC SQERTYSKFY
GLIGERFAKI NRLWSDLFEA AFAKYYDTIH RYETNRLRNI ARFFGHMLST DAIGWHVMSV
IHLNEDETTS SSRIFIKILF QDLGEHLGLA KLQERMRDEI LRPSFEGLFP LDNPRNTRFS
INYFTSIGFG ILTEDMREHL KNLPKPTVPA LPARDAESDS ESVSSHSTCS TCTGSSRSRS
RSYSYSRSPS RSRGRRRSIS RGRSYSRSVS GSSRGRSYTP SYSRSRSPVP KSRRRSVSYS
RSRSPAGRRR SSVSRTPPRR VRGKSYDSRS PSRSVTPPRR RTSYSRRDRS YSRSLSRSVT
PPLRAVDARA RGRRYSSQSL SPPRRRAERS VSPQRPPPGR RPRGDSLSRS PSPPPRYARE
QRRRRNSSSA SASRSPPHRD SNRRRSLSRT PPRRGRASDY L
